Classification Based on Function and Mutation Location Flashcards
1
Q
5 mutations based of effect on function
A
loss of function mutation null mutations dominant mutation gain-of-function mutation suppressor mutation
2
Q
what does a loss of function mutation do
A
reduces/ eliminates gene product function
3
Q
what do null mutations cause
A
complete loss of function
4
Q
what’s haplosufficiency
A
when 1 allele is inactivated by mutation, leaving only one functional gene copy
5
Q
what do suppressor mutations do (2nd mutation)
A
either revert or relieve effects of previous mutation
6
Q
what cells do somatic mutations occur in
A
any cell except germ cells
7
Q
what cells do germ-line mutations only occur in
A
germ cells
8
Q
where do autosomal mutations occur
A
on genes on autosomes
9
Q
where do X-linked mutations occur
Y-linked
A
X - on genes on X chromosomes
Y - on genes on Y chromosomes
10
Q
when would somatic mutations have a greater impact
A
if they’re dominant or in males (x linked)
