Classic chemotherapy- part 3 Flashcards
1
Q
what is the function of microtubules?
A
- structural support
- intracellular movement: organelles
- chromosomes seperation during mitosis and meiosis (spindle apparatus)
2
Q
what is microtubule made from?
A
from tubulin dimers made from alpha and beta tublin
3
Q
what are vinca alkaloids?
A
natural products that disrupt microtubule assembly.
Bind to free ab-tubulin dimers
• Disruption of balance between polymerisation and depolymerisation
• Dissolution of microtubules, destruction of mitotic spindle
4
Q
what is taxol?
A
-isolated from the bark of slow growing yew
-Taxol inhibits the disassembly of
microtubules
• Stabilisation of ordinary
microtubules, formation of
abnormal bundles of microtubuli