Ciclo de krebs Flashcards

1
Q

Ciclo de Krebs

A

Respiración celular
En matriz mitocondrial
Aerobicamente

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2
Q

Piruvato a acetil CoA

A
  • Descarboxilación oxidativa
  • Complejo piruvato deshidrogenasa
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3
Q

Complejo piruvato deshidrogenasa

A
  • Piruvato deshidrogenasa (TPP)
  • Dihidropoil transacetolasa (Lipoato y CoA)
  • Dihidropoil deshidrogenasa (NAD y FAD)
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4
Q

Reacciones del ciclo de Krebs

A
  1. Oxalacetato
    ácido citrico sintasa
  2. Citrato
    acotinasa
  3. Isocitrato
    isocitrato deshidrogenasa +1 NADH
  4. a-cetoglutarato
    a-cetoglutarato deshidrogenasa +1 NADH
  5. Succinil-CoA
    succinil tioquinasa +1 ATP
  6. Succinato
    succinato deshidrogenasa +1 FADH
  7. Fumarato
    fumarasa
  8. Malato
    malato deshidrogenasa +1 NADH
  9. Oxalacetato
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5
Q

Reacciones que obtienen NADH

A

Isocitrato- a-cetoglutarato (isocitrato deshidrogenasa)
a-cetoglutarato -Succinil CoA (a-cetoglutarato deshidrogenasa)
Malato- Oxalacetato (malato deshidrogenasa)

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6
Q

Reacciones que obtienen FADH

A

Succinato-Fumarato (succinato deshidrogenasa)

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7
Q

Reacciones que obtienen ATP

A

Succinil CoA- Succinato (succinil tioquinasa)

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8
Q

Producción de ATP en ciclo de krebs

A

1 Acetil CoA = 3 NADH, 1 FADH y 1 ATP= 10 ATP

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9
Q

Reacciones anapleroticas del ciclo de Krebs

A
  • Piruvato carboxilasa (de piruvato a oxalacetato)
  • Fosfoenol piruvato carboxilasa (oxalacetato a PEP)
  • Malica (piruvato a malato)
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10
Q

Regulsción del ciclo de krebs

A
  • Piruvato deshidrogenasa
  • Citrato sintasa
  • Isocitrato deshidrogenasa
  • a-cetoglutarato deshidrogenasa
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11
Q

Arsenico

A

Afecta privato deshidrogenasa y a-cetoglutarato deshidrogenasa

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12
Q

Fluoroacetato

A

Inhibe acotinasa

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