chronic leukaemias - CML Flashcards
1
Q
CML
A
chronic myeloblastic leukaemia
2
Q
pathology of CML
A
excess neutrophils - neutrocytosis
3
Q
PC of CML
A
- anaemia
- massive splenomegaly
- weight loss - XS haemopoiesis, using E
- hyperleukostasis - resp failure
- gout - due to excess proliferation
4
Q
FBC for CML
A
bloods:
sustained and severe pancytopenia
- high WBC >200
- high platelet count
5
Q
Blood film shows
A
all stages of differentiation
6
Q
bone marrow aspirate?
A
hyper cellular
7
Q
Gene assessment
A
Philadelphia Chr - fusion of Chr 22 + 9
produce BCR-ABL gene which drives CML
8
Q
CML tx? success?
A
greatest success story in cancer
CML tx: tyrosine kinase inhibitors (TKIs)
imatinib
dasatinib
allogenic transplantation if TKI fails - rare
