Chromosomes, Genes And DNA Flashcards
Genes
Have a specific chromosomal location - same position in everyone
Humans have about 25,000 genes
Human Genome
The entire DNA sequence
22 autosomes plus 2 sex chromosomes (X and Y)
Nucleoside
Base and sugar
Nucleotide
Base and sugar and phosphate
RNA
Ribose sugar has 2 -OH groups
Contains uracil instead of thymine
mRNA, tRNA, rRNA
DNA
from 5’ to 3’ is L to R
2-deoxyribose contains one less -OH Contains thymine instead of uracil Anti-parallel strands Right Handed Double Helix Minor groove is more flexible than the major group 5'Phosphate 3'OH
Nitrogenous bases
Purines (2 ring structure) - Adenine and Guanine
Pyrimidines (1 ring structure) - thymine and cytosine
A to T (U in RNA) double bond
G to C triple bond
DNA packaging
Nucleosome - DNA and histone core
Beads on a string - loosely packed - EUCHROMATIN - genes expressed (lighter staining)
Solenoid (30nm fibre) - densely packed - HETEROCHROMATIN - genes not expressed (darker staining)