Cholesterol and its Derivatives

Question 1

In its free form, how many carbon atoms are there in cholesterol?

Answer 1

27

Question 2

All the carbon atoms in cholesterol are derived from what?

Answer 2

Acetyl CoA

Question 3

Where does cholesterol synthesis occur?

Answer 3

cytoplasm

Question 4

what is the rate limiting step in cholesterol synthesis

Answer 4

the synthesis of mevalonate

Question 5

When is HMG CoA active?

Answer 5

When ATP levels are high

Question 6

stain drugs do what to HMG CoA reductase?

Answer 6

they are structural analogs - they reversibly, competitively inhibit it and are therefore used to treat hypercholesterolemia

Question 7

In what organ is most of the bodies’ cholesterol made?

Answer 7

liver

Question 8

what is a rate determining enzyme in cholesterol synthesis?

Answer 8

7a-hydroxylase

Question 9

choledocholithiasis may lead to lipid malabsorption leading to deficiency of what?

Answer 9

essential faty acids and vitamin A, D, E, K

Question 10

where is the highest concentration of CoQ10 found?

Answer 10

inner membrane of the mitochondria

Question 11

what does dolichol play a role in?

Answer 11

co-translational N-glycosylation of proteoglycans and glycoproteins