Chemo

Question 1

Alkylating agents

Answer 1

Cyclophosphamide, ifosfamide
Methilation of DNA bases, cross linking, inh of replication
In breast and sarcoma

Question 2

Taxanes

Answer 2

Paclitaxel, docataxel
Binds, stabilises microtubules, inh anaphase
In breast, lung, prostate
se: slope is, peripheral neuropathy

Question 3

Vinka alkaloid

Answer 3

Vincristine
Failure of mitotic spindle
In lung, mesothelioma, sarcoma
Se: peripheral neuropathy

Question 4

Platinums

Answer 4

Cisplatin, carboplatin, oxiplatin
Cross linking of DNA strands, stops replication
In breast, lung, HPB, H&N, radiosenitiser
Se: emetogenic, ototoxicity, nephrotoxicity, peripheral neuropathy

Question 5

Antimetabolites

Answer 5

5FU, methotrexate, gemcitabine
Stops DNA synthesis
In colon, HPB, breast, sarcoma, lung
Se: palmar plantar erythema, diarrhoea, mucocitis

Question 6

Topoisomerase 1 inh

Answer 6

Irinotecan, topotecan
Inh topo 1, stops DNA replication
In colon, HPB, lung
Se: alopecia, diarrhoea

Question 7

Topoisomerase 2 inh

Answer 7

Doxorubicin, epirubicin
Inh topo 2, stops DNA replication, generates free radicals causing DNA damage
In breast, sarcoma
Se cardiomyopathy, alopecia, vesicant