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COM MOD 2 > Chapter 7 Tables > Flashcards

Chapter 7 Tables Flashcards

1
Q

cancer related to arsenic (2)

A

lung and skin carcinoma

ex. metal smelting, drinks

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2
Q

cancer related to asbestos (4)

A

lung, esophageal, gastric, colon carcinoma

ex. fire, heat, friction using appliances

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3
Q

cancer related to benzene (1)

A

acute myeloid leukemia

ex. light oil, paint, rubber, dry cleaning

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4
Q

cancer related to beryllium (1)

A

lung carcinoma

ex. missile fuel

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5
Q

cancer related to cadmium (1)

A

prostate carcinoma

ex. yellow pigments and phosphorus, batteries

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6
Q

cancer related to nickel (2)

A

lung and oropharyngeal carcinoma

ex. nickel plating

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7
Q

cancer related to radon (1)

A

lung carcinoma

ex. underground mines

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8
Q

cancer related to vinyl chloride (1)

A

hepatic angiosarcoma

ex. refrigerant

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9
Q

cancer related to chromium (1)

A

lung carcinoma

ex. preservatives

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10
Q

neoplasm associated with inflammatory bowel diseases

A

colorectal carcinoma

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11
Q

neoplasm associated with pancreatitis

A

pancreatic carcinoma from alcohol or mutation

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12
Q

neoplasm associated with barrett esophagus

A

esophageal carcinoma from gastric acid

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13
Q

neoplasm associated with hepatitis

A

hepatocellular carcinoma from hepatitis B and/or C virus

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14
Q

neoplasm associated with chronic cervitis

A

cervical carcinoma from HPV

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15
Q

neoplasm associated with chronic cystitis

A

bladder carcinoma

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16
Q

neoplasm associated with gastritis/ulcers

A

gastric adenocarcinoma, MALT lymphomas from H. pylori

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17
Q

nuclear regulatory proteins for selected oncogenes

A

transcriptional activators

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18
Q

proto-oncogenes of nuclear regulatory proteins

A

MYC and NMYC

19
Q

mode of activation in tumor for MYC

A

translocation- burkitt lymphoma and neuroblastoma

20
Q

mode of activation in tumor for NMYC and LMYC

A

amplification- neuroblastoma

21
Q

cell cycle regulators for selected oncogenes

A

cyclins and cyclin-dependent kinase

22
Q

proto-oncogenes of cyclins

A

CCND1 (cyclin 1)

23
Q

proto-oncogenes of cyclin-dependent kinase

A

CDK4

24
Q

mode of activation in tumor for cyclin 1

A

translocation- mantle lymphoma and multiple myeloma

amplification- breast and esophageal cancer

25
Q

mode of activation in tumor for CDK4

A

amplification or point mutation- glioblastoma, melanoma, sarcoma

26
Q

gene inhibitors of mitogenic signaling pathways (7)

A

APC, NF1, NF2, PTCH, PTEN, SMAD2, SMAD4

27
Q

gene inhibitors of cell cycle progression (2)

A

RB, CDKN2A

28
Q

gene inhibitors of “Pro-growth” programs of metabolism and angiogenesis (4)

A

VHL, STK11, SDHB, SDHD

29
Q

gene inhibitors of invasion and metastasis (1)

A

CDH1

30
Q

gene inhibitors of genomic instability (1)

A

TP53

31
Q

gene DNA repair factors (5)

A

BRCA1, BRCA2, MSH2, MLH1, MSH6

32
Q

gene unknown mechanism for cancer

A

WT1, MEN1

33
Q

APC in cancer

A

function: inhibits WNT signaling
defect: causes familial colonic polyps and carcinomas and sporadic carcinomas of stomach, colon, pancreas, and melanoma

34
Q

NF1 in cancer

A

function: inhibitor of RAS/MAPK signaling
defect: causes neurofibromatosis 1 and sporadic neuroblastoma, myeloid leukemia

35
Q

NF2 in cancer

A

function: cytoskeletal stability
defect: causes neurofibromatosis type 2 and sporadic schwannoma and meningioma

36
Q

RB in cancer

A

function: inhibitor of G1/S transition
defect: causes familial retinoblastoma syndrome and sporadic retinoblastoma and osteosarcoma

37
Q

CDKN2A in cancer

A

function: p16; negative regulator of CDK and p14; indirect activator of p53
defect: causes familial melanoma and sporadic pancreatic breast and esophageal carcinoma

38
Q

VHL in cancer

A

function: inhibitor of hypoxia-induced transcription factors defect: causes Von Hippel Lindau syndrome and sporadic renal cell carcinoma

39
Q

TP53 in cancer

A

function: cell cycle arrest and apoptosis in response to DNA damage
defect: causes Li-Fraumeni syndrome and sporadic human cancers

40
Q

BRCA1 and 2 in cancer

A

function: repair of double-stranded breaks in DNA
defect: causes familial breast and ovarian cancer

41
Q

WT1 in cancer

A

function: transcription factor
defect: causes familial wilms tumor and sporadic wilms tumor

42
Q

Growth factor oncogenes (4)

A

PDGF-b, FGF, TGFa, HGF

43
Q

Growth factor receptor oncogenes (6)

A 
EGF receptor family
FMS-like tyrosine kinase 3
Neurotrophic factor receptor
PDGF receptor
KIT ligand receptor
ALK receptor
44
Q

Proteins involved in signal transduction oncogenes (5)

A 
GTP
Nonreceptor tyrosine kinase
RAS 
Notch
JAK/STAT

COM MOD 2 (9 decks)

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