Chapter 5 Flashcards
Side Effects of NSAIDs
Dysepsia, Heartburn, nausea, Vomiting, abdominal pain, peptic ulcer, gastrointestinal bleeding.
COX 1 in stomach and kidney leads to what?
Prostoglandin –>
Bronchodilatation
Vasodilation
Gastric secretion
Platelet Disaggregation
Salt and Water excretion
COX 2 in CNS, gut, macrophages, endothelium, and connective tissue leads to what?
Prostaglandin —>
Bronchodilatation
Vasodilation
Osteoclastactivation
Platelet disaggregation
phagocyte inactivation
inflammation/oncogenesis
COX 1 in platelets leads to what?
Platelet Aggregation
Vasoconstriction
Lipoxygenases leads to what?
Bronchoconstriction
Vasoconstriction
Inflammation
Phagocyte activiation
Adrenal Cortex Produces….?
CorticSteriods
Androgens (anabolic steriods)
Adrenal Medulla Produces…?
Epinephrine
Norepinephrine
(Fight or Flight)
Structure of steroids
The structure between Cortico and Andro steriods is very similar in that they both have four-ring carbon structures.
Corticosteriod function
Serve as metabolic and electrolyte regulators of the organ systems in the body.
Corticosteroid classes
Mineralcorticosteriods: regulate electrolyte balance
Glucocorticosteroids: regulate carbohydrate metabolism
Inhaled Corticosteroids
Should not use for acute Asthma attack.
Effects are not seen for 1-4 weeks
Side Effects of Corticosteriods
Tendon ruptures
decreased bone density
Fluid retention
GI upset
Repositioning of fat to the central body.
Bronchodilators
are B-adregenic agonists which cause widening of the bronchi and bronchioles.
IN athletes EIB (exercise induced bronchspasm) is hte primary cause of bronchoconstriction requiring treatment with bronchodilators such as (albuterol)
Bronchodilator Side effects
Tremor
Nervousness
Dizziness
headache
Nausea
tachycardia
Bactericidal
Cause bacterial cell death
