Chapter 17 Flashcards

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1
Q

What genera make up the family Neisseriaceae?

A

Neisseria
Kingella,
Eikenella,
Simonsiella,
Alysiella, and several other genera.

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2
Q

General characteristics of Neisseria spp.

A

mbost Neisseria spp. are
aerobic,
nonmotile,
non- spore-forming
gram-negative diplococci.

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3
Q

Which Neisseria spp are are rod shaped

A

Neisseria elongata, Neisseria weaveri, and Neisseria bacilliformis are known exceptions and are rod shaped.

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4
Q

All Neisseria species are cytochrome oxidase and catalase positive except for

A

N. elongata subsp. nitroreducens and N. bacilliformis, which are catalase negative.

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5
Q

Many Neisseria spp. are capnophilic? T/F?

A

T

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6
Q

Can Neisseria spp. grow anaerobically and how?

A

Yes. If the alternative electron acceptors are available such as Nitrites.

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7
Q

Where are the natural habitats of Neisseria spp.

A

mucous membranes of the respiratory and urogenital tracts

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8
Q

Neisseria gonorrhea is also known as

A

GonoCOCCI

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9
Q

Neisseria meningitidis is also known as

A

MeningoCOCCI

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10
Q

All Neisseria genera are oxidase positive?

A

True!

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11
Q

All Neisseria genera are catalase negative except

A

Neisseria

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12
Q

Which species of Neisseria are pathogenic

A

Neisseria gonorrhoeae
Neisseria meningitidis
*Neisseria weaveri (bacillus)

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13
Q

Which species of Neisseria is normal oral flora biota of dogs and can be found in bite wounds.

A

Neisseria weaveri (bacillus)

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14
Q

morphologically and biochemically similar to the Neisseria spp. but is NOT a member of the family Neisseriaceae

A

M. catarrhalis

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15
Q

Growth requirements for N. gonorrhoea and N. meningitidis?

A

Both N. gonorrhoeae and N. meningitidis require iron for growth.
They compete with their human host by binding human transferrin to specific surface receptors.
OF NOTE:

Transferrin is a blood plasma glycoprotein that plays a central role in iron metabolism and is responsible for ferric-ion delivery. Transferrin functions as the most critical ferric pool in the body. It transports iron through the blood to various tissues, such as the liver, spleen, and bone marrow.

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16
Q

Commensalis in the upper RT of dogs

A

N. weaveri

17
Q

Virulence factors of Neisseria

A
  • Receptors for human transferrin
  • Capsule (N. meningitidis)
  • Pili (fimbriae)
  • Cell membrane proteins
  • Endotoxin
  • Lipooligosaccharide (LOS)
  • IgA protease
18
Q

What differentiates N. gonorrhea in the 5 morphologically distinctive colony types T1-T5

A

The presence or absence of Pili.
* fine hairlike projections that are important in:
- The initial attachment of the organism to host tissues.
- Inhibits phagocytosis of organism by neutrophils
- Aids in exchange of genetic material between cells

19
Q

Which colony types of N. gonorrhea a virulent. Do they possess Pili?

A

T1-T2. They possess PILI AND ARE VIRULENT!

20
Q

Which N. gonorrhea colony type are avirulent and do they possess Pili?

A

T3-T5 and they DO NOT HAVE PILI!

21
Q

Gonorrhea infection is _________ and which cells it affects

A

Acute pyogenic
NON-Ciliated COLUMNAR AND TRANSITIONAL EPITHELIUM

22
Q

Gonorrhea incubation period

A

2-7 days

23
Q

Protein I function and other name

A

Porin protein (Por)
Nutrient and waste exchange via channels

24
Q

Genes that encode Por protein

A

porA and porB

25
Q

Which Neisseria species encodes both porA and porB genes

A

N. meningitidis

26
Q

Which Neisseria species expresses only porB genes

A

N. gonorrhea

27
Q

What other function does porB serve

A

Protective against the hosts inflammatory response and serum complement-mediated killing.

28
Q

Symptoms of gonorrhea in men

A

Acute urethritis that results in purulent discharge and dysuria. Complications include prostatitis and epididymitis.

29
Q

Most common site of gonorrhea infection in women

A

ENDOCERVIX

30
Q

Symptoms of gonorrhea infection in women

A

Dysuria, cervical discharge and lower abdominal pain.
Complications for untreated infection: PID which may cause sterility, ectopic pregnancy or perihepatitis (FITZ-HUGH-CURTIS Syndrome)

31
Q

Blood borne dissemination of N. gonorrhea results in

A

Purulent arthritis

32
Q

Most disseminated gonorrhea infections are found in males or females? And a due to which strain?

A

Females.

Arginine Hypoxanthine Uracil strain (AHU).

33
Q

Which anticoagulant inhibits N. gonorrhea

A

Sodium Polyanethol Sulfonate (SPS)
* add gelatin to neutralize inhibitory effects of SPS

34
Q

N. gonorrhea in newborns is called

A

OPTHALMIA NEONATORUM. Can result in blindness if untreated

35
Q

What antibiotic eye drops placed in newborn eyes to prevent N. gonorrhea

A

Erythromycin

36
Q

N. gonorrhea specimen of choice in men and women

A

Men: urethra
Women: endocervix

37
Q

What type of swabs are inhibitory to gonorrhea

A

Calcium alignate & cotton