ch 28 paraneoplastic synds

Question 1

if see Eye movement Ds
Opsoclonus
–(in association with cerebellar and brainstem dysfunction)

Answer 1

-d/t neuroblastoma in kids

Question 2

if see Lambert-Eaton myasthenic synd

Answer 2

-d/t abs against the voltage gated Ca channel in the presynaptic element of the NMJ

Question 3

if see Subacute cerebellar degeneration

–(Destruction of purkinje cells, gliosis, and mild chronic inflammatory cell infiltrate)

Answer 3

-d/t ovarian, uterine, or breast carcinoma –> PCA-1 ab (anti-Yo) recognizes the cerebellar purkinje cells

Question 4

if see Subacute sensory neuropathy

Answer 4

-d/t limbic encephalopathy

Question 5

if see Limbic encephalitis

–(subacute dementia, perivascular inflammatory cuffs, microglial nodules, some neuronal loss, and gliosis)

Answer 5

• d/t small cell carcinoma of the lung –> ANNA-1 ab (anti-Hu) that attacks neuronal nuclei in the CNS and PNS
• d/t ovarian teratomas –> ab against the NMDA receptor that cross reacts with hippocampal neurons
• abs against the voltage gated potassium channel (VGKC) comple