Cerebellar microarchitecture

Question 1

What are the 3 layers of the cerebellum?

Answer 1

Molecular
Purkinje cell
Granular

Question 2

What is the main output and input to the cerebellum

Answer 2

Input= mossy fibre
Output= purkinje cells

Question 3

What synapses onto a purkinje cell?

Answer 3

Parallel fibres- 150,000 synapses

Climbing fibres- one single input

Question 4

What sort of firing does C.F cause

Answer 4

Complex spikes

Question 5

What is the marr-albus model?

Answer 5

To learn how to make accurate movements there must be an error signal- to let you know when movements arent accurate

Question 6

What occurs when a mossy fibre and climbing fibre fire?

Answer 6

Depression of the parallel fibre/ purkinje cell synapse

Question 7

What is the de-correlation learning rule?

Answer 7

Learning stops when there is no longer a correlation between any PF signal and CF signal

Question 8

How was this theory tested

Answer 8

vestibulo-ocular reflex

inactivation of flocculus prevents VOR adaptation

Question 9

Apart from motor control what else does the cerebellum effect

Answer 9

1. Sensory prediction- tickling
2. Emotional and cognitive processing
3. Autism, dyslexia and schizophrenia

Question 10

What do P cells receive?

Answer 10

CF input from a unique region of the inferior olive

Question 11

Where do P cells project?

Answer 11

a unique region of the deep cerebellar nuclei