Cephalosporins

Question 1

List two medications in the first generation, and two medical conditions that first generation best treats and why?

Answer 1

FIRST GENERATION:
*Cefazolin and cephalexin
SKIN INFECTIONS (Due to great gram positive coverage)
SIMPLE UTI’s (Due to so-so gram negative coverage, but good gram negative coverage such as E,Coli)

Question 2

List two medications in the second generation cephalosporins and what they best treat and why?

Answer 2

SECOND GENERATION:
*Cefuroxine and Cefotetan
Best treat INTRA-ABDOMINAL INFECTIONS (Due to second generation cephalosporins having anaerobic coverage.

Question 3

List three medications in the third generation of cephalosporins and what they best treat and why?

Answer 3

THIRD GENERATION:
*Ceftriazone/most commonly used for community acquired pneumonia.
*Ceftazidime treats pseudomonas. (Pseudomonas is a particular bacteria often acquired in the nursing home in particular in their lung)
*Ceftaxime is also included in third generation.
THIRD GENERATION best treats lung infections or community acquired pneumonia as it best treats the gram positive bacteria Pneumococcus.
THIRD GENERATIONS also has one of the best gram negative coverage’s out of all the generations of cephalosporins

Question 4

What medication in the third generation treats Pseudomonas?

Answer 4

Ceftazidime

Question 5

Name a fourth generation cephalosporin and what its best to treat and why?

Answer 5

Cefepime. Treats Pseudomonas, also treats serious infections as this fourth generation cephalosporin has strong gram positive and gram negative coverage.

Question 6

List two fifth generation cephalosporins. what are they? a what are they made up of? what do they best treat?

Answer 6

FIFTH GENERATION:
Ceftolozane/Tazobactam
Ceftolozane is an anti-pseudomonal and tazobactam is a beta lactamase inhibitor. This medication with these in combination makes a potent anti-pseudomonal medication.

Ceftaroline is another fifth generation and treats MRSA

Question 7

Which is the only cephalosporin that treats MRSA?

Answer 7

Fifth generation medication - Ceftaroline

Question 8

List the three cephalosporins that are antipseudomonal?

Answer 8

3rdG/Ceftazidime
4thG/Cefepime
5thG/Ceftolozane/tazobactam

Question 9

List the three cephalosporins that best treat community acquired pneumonia..

Answer 9

THIRD GENERATION
Ceftriaxone
Cefotaxime
Cefazidime (P COVERAGE)

Question 10

Name the only cephalosporin that treats MRSA

Answer 10

Fifth generation - ceftaroline

Question 11

List the only two cephalosporin generations with anaerobic coverage?

Answer 11

SECOND AND FIFTH GENERATION.