Cells of Inflammation

Question 1

How would you differentiate a lymphocyte from a monocyte?

Answer 1

Lymphocytes typically are deeper staining (purple) and have less cytoplasm

Question 2

What are the Dominant cellular players in chronic inflammation?
- morphological features?

Answer 2

Macrophage

• Large oval Nucleus that may be indented but NEVER segmented

Question 3

What are some key morphological features of plasma cells?

Answer 3

• Off Centered Nucleus
• Chromatin in a Clockface arrangement
• Light area where golgi sits just outside the nucleus

Question 4

What type of cell contains major Basic Protein and Absorbs Eosin Dye avidly?
- what does the nucleus of these cells typically look like?

Answer 4

Eosinophil

• These usually have a bi-lobed nucleus

Question 5

T or F: the granules of mast cells avidly take up heatoxylin dye making them appear deep blue.

Answer 5

True

Question 6

What cells make up multinucleated giant cells?

• what are the two most common types?
• differences?

Answer 6

• Foreign Body Type
• Langhans Type

*The foreign body type of macrophages ahve disorganized nuclei while the Langhans types have nuclei arranged in a circle.

Question 7

What are the two types of granuloma?

- how do their etiologies differ?

Answer 7

Foreign body:
- caused by a persistent material that is too large or undigestible for clearance

Immune:
- persistent antigen induces cell-mediated immune reaction

Question 8

How does an epithelioid histiocyte differ from a regular macrophage?

Answer 8

**Epitheliod has lots of cytoplasm with medium sized nucleus