Cell Skelebones Flashcards
What charge is at the centrosome?
Negative
What is the charge at the end of a microtubule?
Positive
What molecular motor carry’s cargo to the end of a synapse?
Kinesin
What molecular motor carries cargo from the synapse to the cell body?
Dynein
How does kinesin “walk”?
Releases ADP and binds ATP to cause the lunge forward
What are the 2 polymers of tubulin?
Alpha and beta
How do microtubules act?
Growing and shrinking
What happens when there’s a GTP-capped end on the microtubule?
Rapid growth
What happens to the microtubule when the GTP-capped end is lost?
Shrinks
How is the GTP cap lost?
Hydrolysis catching up to the growth
Which subunit of tubulin holds the GDP/GTP?
Beta
Why are GDP-tubulin dimers unstable?
GDP causes a curve in the tubulin and leads to the dimers no longer supporting each other
What can stabilize microtubules?
Capping proteins
Why is dynamic instability good?
Can rapidly remodel the cytoskeleton, uses GTP hydrolysis to energize certain reactions, and the cell itself can move
