Cell signalling (not the pathways)

Question 1

who were the two men who discovered GPCRs

Answer 1

Brian Kobilka and Robert Lefkowitz

Question 2

which one was into the crystalography?

Answer 2

Brian Kobilka

Question 3

What are the advantages of X-ray crystallography? (3)

Answer 3

structure, size, and weight

Question 4

name the 6 messenger classes, visualizing each

Answer 4

Amines, peptides, eicosanoids, steroids, gases, and purines

Question 5

who received a nobel prize in 1986 for work with NGF dimers

Answer 5

Rita Levi-Montalcini

Question 6

What are the three ways that a response can halted in a cell with regards to the ligand?

Answer 6

The ligand can be drawn into the bloodstream and degraded
The ligand can be drawn away and eaten by another cell
The ligand can be degraded by extracellular enzymes

Question 7

What are the three ways that a response can be halted with regards to the receptor and the ligand?

Answer 7

The unit is phagocytosed and broken down
The receptor is phosphorylated, preventing it from functioning
The secondary messenger is inactivated