CCP Pharmocology

Question 1

Class and MOA for clopidogrel

Answer 1

Antiplatlet agent, P2Y12 antagonist

Irreversibly blocks the P2Y12 component on platelet surfaces, preventing activation of the glycoprotein 11a/11b complex, reducing platelet aggregation.

Question 2

Class and MOA of dobutamine

Answer 2

Adrenergic agonist/ inotrope

• dobutamine acts on myocardial beta 1
• some alpha I agonist resulting in increased contractility and HR
  -stimulates both beta 1 and alpha 1 receptors in vasculature. Resulting in some vasodilation in addition to the inotropic and chronotropic actions
• lowers central venous pressure and wedge pressure but has little effect on pulmonary vascular.

Question 3

Class and MOA of furosemide

Answer 3

Antihypertensive, loop diuretic

• inhibits the reabsorption of sodium and chloride in the ascending loop of henle as well as the proximal and distal tubules

Question 4

Class and MOA of haloperidol

Answer 4

Antipsychotic

Blocks post-synaptic mesolimbic dopaminergic receptors in the brain

Question 5

Class and MOA of hydrazaline

Answer 5

-antihypertensive

-vasodilator by prevention of calcium influx into vascular smooth muscle which then relaxes arterial smooth muscle and lowers BP

Question 6

Class and MOA of labetolol

Answer 6

Selective alpha and non-selective beta-adrenergic blocker

Completely blocks Beta receptors within the myocardium and within bronchial and vascular move muscle as well as alpha receptors in vascular smooth muscle.

Indicated in hypertensive crisis

Question 7

Class and MOA of metoclopramide

Answer 7

Antiemetic, dopamine antagonist

Blocks dopamine receptors in the chemoreceptor trigger zone of the CNS, enhances gastric motility and accelerates gastric emptying

Question 8

Class and MOA of metoprolol

Answer 8

Beta-1 selective beta blocker

Preferential Inhibitory effect on beta-1 adrenoreceptors, located primarily in cardiac muscle. High doses can exert beta 2 effects

Question 9

Class and MOA of norepinephrine

Answer 9

Alpha 1 and beta 1 agonist

Stimulates alpha and beta 1 adrenergic receptors causing increased contractility (inotrope) dromotropy and vasoconstriction

Question 10

Class and MOA of phenytoin

Answer 10

Anticonvulsant

Stabilizes neuronal membranes and decreases seizure activity by lowering intra cellular sodium levels in the motor cortex,

it also prolongs the refractory period and suppresses ventricular pacemaker automaticity, shortening action potential in the heart

Question 11

Class and MOA of ketamine

Answer 11

Non-competative NMDA receptor agonist that blocks glutamate.

General anastethic, analgesic, sedative

Question 12

Class and MOA of propofol

Answer 12

GABA receptor agonist

Question 13

Class and MOA for succinylcholine

Answer 13

Depolarizing neuromuscular blocking agent

Depolarizes motor endplate by binding to acetylcholine receptors

Question 14

Class and MOA of rocuronium

Answer 14

Non-depolarizing neuromuscular blocking agent

Produces skeletal muscle relaxation by inhibiting the activity of acetylcholine at the neuromuscular junction.

Does not alter the resting membrane potential of the motor end plate or cause muscular contraction