CCBs

Question 1

Which CCBs are not dihydropyridine CCBs

Answer 1

diltiazem and verapamil

Question 2

what condition should diltiazem and verapamil be avoided in

Answer 2

HF - may further depress cardiac function

Question 3

The BNF reiterates like 1000x that verapamil should absolutely not be used with what class of drugs?

Answer 3

Beta blockers - hypotension and asytole

Question 4

what is the most common side-effect of verapamil

Answer 4

constipation

Question 5

what CCB is used for Raynauds?

Answer 5

Nifedipine - relaxes vascular smooth msucle and dilates coronary arteries and bloodd vessels

Question 6

main side-effects of CCBs (2)

Answer 6

• flushing and headache (transient)

- ankle swelling (may respond only partially to diuretics

Question 7

which 2 CCBs are most often used?

what is a potential reason for this?

Answer 7

felodipine and amlodipine

once a day administration

Question 8

symptoms of CCB poisoning

Answer 8

nausea
vomiting
dizziness
agitation
confusion
coma

Question 9

which CCBs should be prescribed by brand

Answer 9

diltiazem - different MR preparations containing over 60mg may have differing effects
Nifedipine MR preparations

Question 10

what CCB can be used to postpone premature labour

Answer 10

nifedipine

Question 11

what should be suspected in patient treated with hydralazine presenting with arthritis and weightloss

Answer 11

systemic lupus erythematosus (incidence lowest if dose kept under 100mg)