Case 1 definitions

Question 1

Morphine sulfate: brand (starts with A lol) type, polymer

Answer 1

Avinza; spansule; uses methacrylate polymer

Question 2

Morphine sulfate: brand (starts with K), type, what makes pellets?

Answer 2

Kadian; spansule; EC (ethyl cellulose), PEG (poythylene glycol); methacyrlate

Question 3

Morphine sulfate: brand (starts with MS), polymer matrix, what type of interactions

Answer 3

MS Contin; hydrophilic polymer (HPMC), hydrophoblic polymer (HEC); diffusion of drug into aqueous phase, constant and predictable relationships

Question 4

Oxycodone HCl: brand, type, what makes up matrix

Answer 4

Oxycodone HCl; dual controlled matrix of hydrophobic polymers; GI fluid enters tablet matrix and dissolves entrapped drug

Question 5

Hydrocodone bitartrate: band, pellet types; why we need it

Answer 5

ZohydroER; coated carrier beads in hard gelatin capsules, hydrocodone bitartrate, rate controlling polymers, drug is released by diffusion out of the polymers; opioids maintain pivotal role in managing chronic pain

Question 6

NSAIDS; brand, what it treats

Answer 6

Vimovo, treats osteoarthritis & RA; decreased risk of developing NSAID associated gastric ulcers

Question 7

what covers the sugar of spansules

Answer 7

microcrystalline cellulose

Question 8

methylphenidate HCl

Answer 8

Ritalin LA / spansules

Question 9

amphentamine salt

Answer 9

Adderall XR / spansule

Question 10

what is the coating in delayed release

Answer 10

waxes and cellulose acetate phthalate (CAP)

Question 11

aspirin prilosec

Answer 11

delayed release

Question 12

ambien CR

Answer 12

Zolpidem ER / repeat action tablets

Question 13

two tpes of microencapsulation

Answer 13

coacervation / spray drying

Question 14

micro-K enencaps

Answer 14

potassium chloride

Question 15

what is used in slowly eroding matrix tablets

Answer 15

hydrophillic cellulose polymer

Question 16

Vermapril HCl

Answer 16

Calan? / slowly eroding matrix tablets

Question 17

osmotic agents

Answer 17

NaCl or mannitol

Question 18

example of osmotic pumps

Answer 18

Methylphenidate HCl (Concerta)

Question 19

Tussinex

Answer 19

hydroodone chloripheniamine / ion exchange resins

Question 20

mechs of oral MRDF (3 ways)

Answer 20

modify drug dissolution by controlling access of biologic fluids using barrier coatings; control diffusion rate from dosage forms; release after interaction between drug substance or excipient barrier and site specific biologic fluids

Question 21

modify drug dissolution by controlling access of biologic fluids using barrier coatings (4)

Answer 21

spansules; DR; RA; microencapsulation

Question 22

control diffusion rate form dosage forms (2)

Answer 22

slowly eroding matrix tablets; inert plastic matrix tablets

Question 23

release after interaction between drug substance or excipient barrier and site specific biologic fluids (3)

Answer 23

osmotically controlled systems; osmotic pumps; ion exchanges resins

Question 24

Nitroglycerin Sublingual

Answer 24

Nitrostat, NitroQuck / antianginal, antihypertensive, vasodilator / molded tablet /

Question 25

Fentora

Answer 25

fentanyl citrate / OraVescent / releases CO2 when tablet comes into contact with saliva; recommened buccal then sublingual

Question 26

Zofran ODT

Answer 26

generic?? / Orally disintegrating

Question 27

Zyprexa Zydis

Answer 27

Olanzapine / orally disintegrating / used for schizophrenia

Question 28

Prevacid Solutab

Answer 28

Lansoprazole / orally disintegrating

Question 29

Zuplenz

Answer 29

ondansetron / thin films

Question 30

Singular

Answer 30

montelukast sodium / granules

Question 31

Nexium

Answer 31

Esomeprazole

Question 32

goodys

Answer 32

acetaminophen (aspirin NSAID)