Carcinoid tumour Flashcards
1
Q
What group of tumours is it under?
A
Enterochromaffin cell origin
2
Q
Where are the common sites for it?
A
- Appendix
- Ileum
- Rectum
3
Q
When does carcinoid syndrome occur?
A
When mets to liver
May also occur in lung carcinoid as mediators not cleared by the liver
4
Q
What is carcinoid syndrome?
A
Release of serotonin, kinins, histamines, PGs into the circulation
5
Q
What are the SX?
A
Flushing (1) Diarrhoea Bronchospasm HypoTN R valvular stenosis LH affected in bronchial carcinoid Cushing's syndrome - as ACTH may also be released
6
Q
What are the IX?
A
Urinary 5-HIAA (breakdown product of serotonin)
Plasma chromogranin A y
Liver CT - mets
7
Q
How is it MX?
A
Ocreotide (somatostatin analogue)
- inhibits release of hormones
Surgical resection
Diarhhoea - cyproheptadine
