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NEOPLASIA > CARCINOGENS AND ASSOCIATED CANCERS > Flashcards

CARCINOGENS AND ASSOCIATED CANCERS Flashcards

1
Q

Aflatoxins

A

Hepatocellular carcinoma [Aspergillus produces aflatoxins]

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2
Q

Alkylating agents

A

Leukemia/ Lymphoma [Side effect of cancer chemotherapy]

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3
Q

Arsenic(3)

A
  1. Squamous cell carcinoma of the skin
  2. Lung cancer
  3. Angiosarcoma of the liver
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4
Q

Asbestos (2)

A
  1. Lung carcinoma (most likely)

2. mesothelioma

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5
Q

Cigarette smoke (5)

A 
It has 40 carcinogens.
It causes carcinoma of:
1.oropharynx
2.esophagus
3.pancreas
3.kidney (urothelial cancer)
4.bladder (urothelial cancer)
5.lung
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6
Q

Nitrosamines

A 
Stomach carcinoma (intestinal type)
It is present in SMOKED FOOD
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7
Q

Naphthylamine

A

Urothelial carcinoma of the bladder. It is present in CIGARETTE SMOKE,

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8
Q

Vinyl chloride

A

Angiosarcoma of the liver

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9
Q

Ni, Cr, Be, Silica

A

Lung carcinoma

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10
Q

VIRUS: EBV (HHV-4)

A
  1. Nasopharyngeal carcinoma
  2. Burkitt’s lymphoma
  3. CNS lymphoma in AIDS
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11
Q

VIRUS: HHV-8

A

Kaposi sarcoma ( Tumor of endothelial cells)

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12
Q

VIRUS: HBV (Hep B) and HCV (Hep C)

A

Hepatocellular carcinoma

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13
Q

VIRUS: Human T-cell Leukemic Virus-1 (HTLV-1)

A

Adult T cell leukemia/ lymphoma

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14
Q

VIRUS: High-Risk Human Papilloma Virus (HPV).

Subtypes

A

Subtypes: 16, 18,31, 33

  1. Squamous cell carcinoma of vulva, vagina,anus,and cervix
  2. Adenocarcinoma of cervix
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15
Q

Ionizing Radiations (CARCINOMAS)

A
  1. Acute myeloid leukemia (AML)
  2. Chronic myeloid leukemia (CML)
  3. Papillary carcinoma of the thyroid
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16
Q

Ionizing Radiations (MECHANISM)

A

Generates hydroxyl free radicals

17
Q

Non-ionizing Radiations (UV-B) (CARCINOMAS)

A
  1. Basal cell carcinoma
  2. Squamous cell carcinoma
  3. Melanoma of skin
18
Q

Non-ionizing Radiations (UV-B) (MECHANISM)

A

Results in the formation of pyrimidine dimers, which are usually excised by restriction endonucleases. But in some diseases e.g. Xeroderma pigmentosum, restriction endonucleases don’t work.

NEOPLASIA (1 decks)

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