Carbohydrates 8 Flashcards
What are the different types of immunoglobulin?
IgG
IgA
IgE
IgD
IgM
have distinct glycosylation patterns that confer unique functions by affecting their affinities for immune receptors
immunoglobulin types
important in self/non-self identity in tissue rejection and autoimmune diseases
glycans
one of the five types of glycosylation that occurs to proteins in all kingdoms of biology
O-linked glycosylation
O-linked glycosylation is initiated primarily in the ___________ of eukaryotic cells
Golgi apparatus
Where does the modification in O-linked glycosylation occur?
oxygen of the hydroxyl group of serine, threonine, tyrosine
True or False: Amino acids that become hydroxylated through post-translational modification cannot be involved in O-linkages.
False; can
membrane or secreted glycoproteins that have many O-linekd oligosaccharide chains and are present in most bodily secretions
mucins
Other sugars attached to proteins via O-linkages include:
fucose
glucose
N-acetylglucosamine
mannose
important fibrous protein whose lysine residues are commonly hydroxylated in post-translational modification
collagen
can be linked via their O-groups to galactose followed by attachment of glucose residues to galactose
hydroxyls
formed in collagen, but is not a target for glycosylation
hydroxyproline
rarest and least understood protein glycosylation
c-linked glycosylation
commonly occurs as a link between a mannose residue and a tryptophan side chain
C-linked glycosylation
protein amino acid sequence where C-linked glycosylation occurs is
Trp-X-X-Trp
