Cancer meds

Question 1

CLASS: 6-MP (Mercaptopurine), 5-FU (Fluorouracil)

Answer 1

Antimetabolites

Question 2

CLASS: Vincristine, Paclitaxel (Taxol)

Answer 2

Plant based

Question 3

CLASS: Dactinomycin, Doxorubicin, Bleomycin

Answer 3

Antibiotics

Question 4

CLASS: Corticosteroids, Tamoxifen, Fulvestrant

Answer 4

Hormonal agents

Question 5

CLASS: Imatinib

Answer 5

Inhibitor

Question 6

CLASS: Trastuzumab, Rituximab

Answer 6

Monoclonal antibodies

Question 7

Cisplatin

Answer 7

Alkylating agent that forms highly reactive platinum complexes, crosslinks, and causes DNA damage and inhibits cell proliferation.

Highly protein bound
Poorly penetrates BBB
Slowly excreted in urine

Uses: Testicular cancer (85-95% curative), ovarian cancer, lung, esphageal, gastric

Question 8

Methotrexate

Answer 8

Inhibits dihydrofolate reductase (DHFR)
Interferes with DNA/RNA synthesis
Antimetabolite

Question 9

Prednisone, hydrocortisone, dexamethasone

Answer 9

Glucocorticoids
Suppress immune response, mimic naturally occurring adrenal corticosteroids

Question 10

Cyclosporin

Answer 10

Calcineurin inhibitors
Necessary for T-cell receptor signalling and activation

Question 11

Azothioprine, cyclophosphamide, hydroxychloroquine

Answer 11

Cytotoxic agents
Kill rapidly proliferating cells

Question 12

Muromonab (CD3), RhoGAM, Adalimumab (TNF-a)

Answer 12

Immunosuppressive antibodies
Created in a lab, directed against cell-surface antigens/receptors

Question 13

Sirolimus, Mycophenylate Mofetil, Thalidomide derivatives

Answer 13

Additional agents