Cancer-Associated Viruses Flashcards
1
Q
Acute vs Chronic cancer viruses
A
Acute viruses directly transform genes. Tumor are polyclonal. Examples are Kaposi’s sarcoma (HHV8) and EBV
Chronic viruses immortalize cells, but need an additional mutation to cause cancer. Tumors are monoclonal. Ex: HPV cervical cancer.
2
Q
HTLV-1
Name
Disease
Endemic area
A
Human T-lymphotropic virus 1
Causes adult T cell Leukemia
Endemic in Japan / Caribbean
3
Q
HHV8
Diseases
Enemic area
A
Causes Kaposi’s sarcoma (endemic to Mediterranean), lymphomas, and Castleman’s disease
4
Q
Which viruses exclusively cause cancer in immunocompromised pxs?
A
EBV and HHV8
