Calcineurin inhibitors

Question 1

mechanism of action of calcineurin inhibitors?

Answer 1

exert their immunosuppressive effects by binding to Calcineurin

Calcineurin in turn is unable to trigger
interleukin-2 (IL-2) production and IL-2 receptor expression, leading to a reduction in T-cell activation

Question 2

Name 2 examples of calcineurin inhibitors?

Answer 2

1. Ciclosporin

2. Tacrolimus

Question 3

What conditions is ciclosporin used for?

Answer 3

1. ulcerative colitis
2. rheumatoid arthritis
3. psoriasis

Question 4

What are the two main side effects of Ciclosporin?

Answer 4

BP and renal function must be checked twice before initiation

1. nephrotoxicity
2. hypertension

Question 5

What is Tacrolimus used for?

Answer 5

Eczema and psoriasis

Question 6

What is apotential side effect of Tacrolimus?

Answer 6

Potential for cardiomyopathy so ECG must be checked regularly