C20 Tissues and Cancer Flashcards
Tissues are composed of ? plus ?
cells plus extracellular matrix
plant cells surround selves with ECM of ? made of ?
cell wall, cellulose
controls orientation of plant growth
deposition of cellulose
fibroblasts
type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing
animals ECM tensile strength provided by ?
collagen
link extracellular matrix proteins to intracellular cytoskeleton
integrins
act as space fillers and resist compression
proteoglycans
proteoglycans formed from ? linked to proteins
GAGs (glycosaminoglycans)
line all internal and external surfaces of animal body
epithelial sheets
? proteins span epithelial cell membranes and attach to similar ones in other epithelial cells
cadherins
adherins junction
cadherins linked intracellularly to actin filaments
desmosome junction
cadherins linked to keratin filaments
tight junctions
seals neighboring cells together to prevent leakage
hemidesmosome junction
anchors intermediate filaments to basal lamina
gap junction
create small pores that connect cells
? in plant cells are similar to gap junctions
plasmodesmata
G-protein in mitogen activated signaling
Ras
chronic myeloid leukemia is often the result of a specific chromosome translocation that increases activity of ?
abl
sonic hedgehog
provides positional information