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Pathology and MuscSkel > Bone Cell bioloby > Flashcards

Bone Cell bioloby Flashcards

1
Q

What is hydroxyapatite?

A

Ca2+ and phosphorus

99% of the body’s calcium is stored in bone

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2
Q

What is the osteoid?

A

type 1 collagen=acidophilia
proteoglycans
glycoproteins; promote hydroxyapatite formation
osteocalcin is bone specific

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3
Q

What is hyaline cartilage composed of?

A

75% water and type 2 collagen

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4
Q

What is bone composed of?

A

70% mineral, 25% water type I collagen and neuronal and vascular structures

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5
Q

What arethe onlyknown osteoblast-specific genes?

A

Cbfa-1 and Osteocalcin

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6
Q

What is the role of Cba-1?

A

transcription factor bone

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7
Q

What growth factor induce osteoblast differentiation?

A

bone morphogenetic proteins

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8
Q

Where are osteocytes located?

A

occupy lacunae between lamellae of bone matrix

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9
Q

What is the role of PTH?

A

activates osteoclasts and leads to bone resorptiona nd Ca2+ release

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10
Q

What is the role of calcitonin?

A

antagonizes processes of PTH

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11
Q

What is the osteoid?

A

type 1 collagens=acidophilia
proteoglycans
glycoproteins; promote hydroxyapatite formation
osteocalcin is bone-specific

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12
Q

What is the role of osteoblasts?

A

specialized fibroblasts

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13
Q

What is the function of osteocytes?

A

half life of 25 years

maintain bone matrix

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14
Q

What is the role of osteoclasts and where are they located?

A

destroy/remodel bone matrix
multinuclear develop from macrophages that fuse together
reside in hollow area of matrix called hollowhsips lacunae

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15
Q

How is bone resorbed by osteoclasts?

A

lysosomes->cathepsin-k-> microenvironment acid-> Destrictuion

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16
Q

Where are osteoblasts located?

A

located in periosteum with smaller number the endosteum

17
Q

What is compact/cortical bone?

A

dnse, no cavitation

18
Q

What is spongy/cancellous bone?

A

cavitation

19
Q

What is the difference between spongy and compact bone microscopally?

A

none

20
Q

What are chondroblasts?

A

secrete a callus of hyaline cartilage

21
Q

What are bone morphogenetic proteins>

A

BMP-2 and BMP-7

Pathology and MuscSkel (15 decks)

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