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5 bone biology > bone biology > Flashcards

bone biology Flashcards

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1
Q

what is the benefit of bone remodelling

A

allows for repair
replacement of old brittle bones
acts as a reservoir for calcium and phosphate ions

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2
Q

what are the phases in remodelling

A
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3
Q

what can be the abnormalities of bone

A
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4
Q

what does this show

A

osteogenesis imperfecta

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5
Q

what does this show

A

osteopetrosis

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6
Q

how can dental extractions affect bone levels

A

bone loss in horizontal and vertical dimensions which can result in a narrower and shorter ridge

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7
Q

how can extractions impact restorative work

A

remodelling process can take 6 months
would need to wait 6b months to make any permanent restorations ie bridges, implants or dentures

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8
Q

name 4 drugs which can effect bone remodelling

A
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9
Q

how do bisphosphonates affect bone

A

they are non metabolised analogues of pyrophosphate that are capable of localizing to bone and inhibiting osteoclastic function

they bind to exposed bone mineral around resorbing osteoclasts

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10
Q

why is the action of bisphosphonates long term

A

they are not metabolised

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11
Q

what are the two classes of bisphonsphonates

A

non-nitorgen containing
nitrogen-containing

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12
Q

what are the differences between non-nitorgen-containing and nitrogen-containing bisphosphonates

A
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13
Q

what are the two risk categories for MRONJ and where can you find the classifications

A

SDCEP - low and high risk

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14
Q

how would you manage a patient are risk of MRONJ before starting drugs

A
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15
Q

what is the criteria for MRONJ

A
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16
Q

what are the signs and symptoms of MRONJ

A
17
Q

what does this show

A

exposed necrotic done

18
Q

what stage of MRONJ is this

A

stage 0

19
Q

what stage of MRONJ is this

A

stage 1

20
Q

what stage of MRONJ is this

A

stage 2

21
Q

what stage of MRONJ is this

A

stage 3

22
Q

what is non opertaive tx of MRONJ

A
23
Q

what are the operative tx for MRONJ

A
24
Q

what does this show

A

exposed necrotic bone

25
Q

is this healthy or unhealthy

A

Bleeding suggests healthy bone as when dead bone there is no bleeding

26
Q

what is denosumab

A

human monoclonal antibody that inhibits osteoclast fucntion but does not bind to bone

27
Q

what fucntion is inhibited by denosumab

A

osteoclast function

28
Q

how does denosumab inhibit osteoclast fcuntiom

A

by inhibiting RANKL

29
Q

what is the clinical relevance of NSAIDs

A

long term NSAIDs can impact on bone healing so may be avoided following bone augmentation surgery for dental implants if possible

30
Q

what is the clinical relevance of steroids

A

many pt take high dose steroids for conddiitions such as COPD or autoimmune disease and as a consequence develop MRONJ

31
Q
A

5 bone biology (3 decks)

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