Bone

Question 1

Inactivating mutations of CASr cause what condition?

Answer 1

Familial hypocalciuric hypercalcemia

Question 2

Activating mutations in CASR
Cause which condition?

Answer 2

Familial hypoparathyroidism hypercalciuria

Question 3

Daily RD allowance for Vitamin D in less adults less than 70 years old?

Answer 3

600 IU

Question 4

Mechanism of bone formation through use of a cartilage network and involving osteoblasts layong down true bone matrix followed by osteoclast driven turnover matrix and cells.

Answer 4

Endochondral bone formation

Question 5

Bone formation markers

Answer 5

BPO
>BAP Bone Alkaline Phosphatase
>Propeptide C terminal and N Terminal propeptide of type 1 Procollagen
>Osteocalcin

Question 6

Causes of Secondary Osteoporosis except:
Hypothyroidism
Depression
Gastric cancer
Fludrocortisone

Answer 6

Depression

Question 7

Secondary Osteoporosis mechanisms except:
1. Uncoupling of remoding unit
2. Enhanced marrow adipogenesis
3. Secondary hypogonadism and hypoparathyroidism
4. Suppression of IG-I

Answer 7

Secondary hyPER parathyroidism

Question 8

Which among the treatments for osteoporosis are Carbon subsituted analgoues of pyrophosphate that bind tightly to hydroxyapatite crystals
1. Strontium Ranellate
2. Denosumab
3. Raloxifene
4. Alendronate

Answer 8

4 alendronate and other bisphosphanates