Blueprints Flashcards
Aphasia
language abnormality
Right hemiparesis
Frustrated
Inability to produce language
Brocha lesion
Lesion in Brocha’s aphasia
posterior inferior frontal gyrus in left
Inability to comprehend
Neologisms
Paraphasia
Contralateral homonymous superior quadrantnopia
Wernicke’s
Lesion in Wernike’s
posterior superior temporal gyrus
Inferior MCA
Conduction aphasia
inability to repeat what is said
Lesion in conduction aphasia
arcuate fasciculus
Global aphasia
Large lesion affecting brocha’s and Wernike’s
Occipital lesion with involvement of the splenium of the corpus callosum causes
Alexia without agraphia
contralateral homonymous hemianopia
Apraxia
inability to perform learned tasks
Agnosia
Inability to recognize objects
prosopagnosia
inability to recognize faces
lesion in angular gyrus
Gerstmann Syndrome
Symptoms of Gerstmann syndrome
agraphia
acalculia
R-L confusion
finger agnosia
Neglect
Lesion in the non-dominant side causes neglect of left side of world
dementia with visual hallucinations
Lewy Body dementia
Chromosomal abnomralities in Alzeheimers’s
Chromosone 1 presenilin 2 Chromosome 12 alpha 2 macroglobin Chromosome 14 Presenilin 1 Chromosome 19 ApoE4 Chromosome 21 APP
Pseudodementia
dementia from depression
Rx of alzehemier’s
Donepezil
Rivastigmine
Memantine
Criteria for vascular dementia
Dementia + one of the following
1) abrupt onset (macrovascular) or step wise (microvascular)
2) focal neurologic sign
3) imaging showing multiple local infarcts or lacunes
Pathogenesis of Lewy Body dementia
alpha syneculin accumulation in the cortical neurons (in parkinson’s alpha syneculin is found in the substantia nigra)
Genetic Defect Huntington
Autosomal dominant CAG repeat on chromosomal 4
Presentation Triad in Huntington
Chorea
Behavioral changes
Dementia
Pathology of Huntington
atrophy of caudate
Loss of inhibitory neurons in basal ganglia
Dementia
failure of vertical gaze
dysarthria, dysphagia
Gait ataxia
Progressive Supranuclear palsy
Atrophy of dorsal midbrain, globus pallidus and subthalamic nuclei
Progressive supranuclear palsy
Behavioral changes followed by dementia
Frontotemporal dementia
Rapidly progressing dementia
myoclonus
Prion related
14-3-3 CSF positive
CJD
Nomral sleep stages ad EEG findings
Stage 1 theta Stage 2 sleep spindles + k complexes Stage 3 Delta Stage 4 50% increase in delta REM
What inhibits stage three sleep?
What inhibits REM sleep?
Stage III Benzos
REM Antidepressants + alcohol
Circadian rhythm us controlled by what area of the brain
suprachiasmatic nucleus
Common deficiency in restless leg syndrome and management
Anemia—assess ferritin level
Treatment of Restless leg syndrome
Dopaminergic agents
Ropinirole
Pramipexole
levodopa
Criteria for Narcolepsy
Excessive daytime sleepiness
Cataplexy
Hypnogogic hallucinations
Sleep paralysis
Pathophysiology of Narcolepsy
loss of hypocretin secreting neurons
Diagnosis of narcolepsy
Decreased hypocretin in CSF
Multi-sleep Latency Test (PSG)
(>2 episodes of REM upon falling asleep)
Treatment of narcolepsy
Modafinil
Methylphenidate
dextroamphetamine
Treatment of cataplexy
TCA: clomipramine
Sodium oxabute
Somnabulism
Interruption of sleep with motor behaviors such as walking, dressing driving
Sleep terrors
No memory
Wake in terror with autonomic signs
Do not occur In REM sleep
REM behavior disorder
punching, kicking, jumping yelling etc during sleep
People with REM have increased incidence of
Parkinsons, Lewy Body demetnia
Treatment of REM behavior disorder
Clonazapam
Treatment for nocturnal cramps
quinine
bitemporal hemianopia
compression of optic chiasm
2’ to aneurysm, pituitary tumor
Disease associated with Saccular aneurysms and common sites
ADPKD
Ehlers-Danlos
Bifurcation of the anterior cerebral and anterior communicating
Charcot-Bouchard microaneurysm
Small vessel aneurysms that result from chronic hypertensions. Most commonly affecting the lenticulostriate vessels of the basal ganglia and thalamus
Central Post stroke syndrome
in 10% of stroke patients, weeks to months after stroke simple stimuli will cause pain. Due to thalamic lesions
Treatment of vasospasm in subarachnoid hemorrhage
nimodipine
Types of herniation from intracereberal hemorrhage
Cingulate
Downward transtentorial
Uncal herniation
Cerebellar tonislar
Signs of transtentorial herniation
altered mental status -occurs first
bilateral small pupils reactive to light -disruption of 1st order sympathetics
Cheyne-Stokes breathing
flexor/extensor posturing
Signs of uncal herniation
ipsilateral blown pupil, nonreactive
Down and out gaze
False localization (ipsilesional hemparesis)
*Commonly from epidural hematoma
Signs of Cerebellar herniation
respiratory arrest secondary to medullary compression. Rapidly fatal.
Epidural hematoma
Lateral skull fracture leading to a bleed in the middle meningeal artery, lens shaped on exam
History and Physical of Epidural hematoma
LOC followed by a lucid interval
Uncal herniation
Subdural hematoma
rupture of bridging veins after trauma causing accumulation of blood between the arachnoid and the dura causing a CRESCENT shaped mass
History and Physical with Subdural hematoma
headache
altered mental status
contralateral hemiparesis
Area most vulnerable to hypoxia
Hippocampus
type of necrosis in the brain
Liquefactive
MCA stroke
Motor upper limb and face-contralateral paralysis
Sensory upper limb and face-contralateral
Aphasia or heminegelct
Anterior Cerebral Artery Stroke
Contralateral Motor paresis to the leg
Contralateral Loss of sensation to the limb
Lenticulostriate artery stroke
Contralateral hemiparesis/hemplegia
Medial Medullary Syndrome
ASA occlusion
Contralateral hemiparesis-lateral corticospinal
decrease contralteral proprioception
Ipsilateral hypoglossal dysfunction
Lateral Medullary Syndrome
PICA stroke
DYSPHAGIA/HOARSNESS-
Vomiting, vertigo, nystagmus
ipsilateral decrease in face pain and temp
contralateral decrease in body pain and temp
ipsilateral horners
Ataxia/dysmetria
Lateral Pontine Syndrome
AICA Stroke Paralysis of face Vomiting, vertigo, nystagmus Ipsilateral pain and temp loss on face Contralateral pain and temp loss body Ataxia Dysmetria
PCA stroke
Contralateral hemianopia with macular sparing
Basilar Artery stroke
“Locked in” Syndrome
Anterior Communicating artery Stroke (or aneurysm)
Visual fields deficits
Posterior Communicating artery stroke
CNIII palsy Down and out with ptosis and mydriasis
Pathway of CSF
Monroe
Sylvius
Luschka/Magendie/Luschka
Idiopathic intracranial hypertension
pseudotumor cerebri
Increased ICP with no cause on imaging
History and physical of pseudo tumor cerebri
Hx: HA, diplopia (CNVI palsy), no metnal status change
PE: Papilledema
RF for pseudotumor cerebri
Childbearing age
Vitamin A excess
Danazol
Treatment of pseudo tumor cerebri
Weight loss
Acetazolamide
Topiramate
Invasive procedures in refractory
Pathophysiology of NPH
expansion of the ventricles OUT OF PROPORTION with the sulci causes expansion of the corona radiata
Clinical Findings in Normal pressure hydrocephalus
Urinary incontinence
Dementia
Magenetic Ataxia
CT/MRI with enlarged ventricles out of proportion with sulci
Treatment of NPH
cerebral fluid shunting
Pathophysiology of Communicating hydrocephalus with symptoms
Decreased CSF reabsorption
Increased ICP
papillidema
herniation
Pathophysiology of Noncommunicating hydrocephalus
Outflow obstruction
Appearance of hydrocephalus from cortical atrophy causing appearance of increased ventricle size
Ex vacuo ventriculomegaly
Characteristics of simple partial seizure
No alteration in consciousness
Motor features such as progressive jerking
Sensory, autonomic and psychic features localized to half body
Characteristics of Complex partial
Alteration of consciousness
Auditory/visual hallucinations
automatisms-lip smacking
Temporal love 70-80%
Management of Partial seizures
EEG for localization and R/O pseudo
Blood work for secondary causes
MRI or CT with contrast
Treatment of recurrent partial seizures (5)
Phenytoin oxcarbazepine carbamazepine phenobarbital valproic acid
First line anticonvulsant in children
Phenobarbital
Treatment for seizure lasting longer than ____ minutes
2 minutes
IV benzodiazepines
phenytoin-prophylaxis
Side effects of medications used to treat status
Benzos: repiratory depression, sedation, tolerance
Phenytoin: megaloblastic anemia, teratogen (fetal hydatoin syndrome), SLE, Steven Johnson, P450 inducer (CI in porphyria)
Side Effects Carbamazepine (6)
Aplastic anemia Hepatotoxicity teratogen P450 inducer (CI in porphyria) SIADH Steven's Johnson Syndrome
Side effects of valproic acid
Hepatotoxic
Neural tube defects
Side effects of first line seizure therapy in children
Phenobarbital sedation tolerance P450 induction cardiorespiratory depression
Characteristics of tonic clonic seizure
Sudden onset
LOC
1-2 minutes of repetitive, symmetric clonic movements
Tongue biting and urinary incontinence are common
EEG for tonic clonic seizure
10 Hz activity during tonic phase
Slow waves during clonic phase