Blood brain barrier

Question 1

what is the function of the BBB

Answer 1

protect the integrity and environemtn of the CNS

blood vessels that pass through are surrounded by an endothelial layer unlike any over blood vessels

Question 2

describe the endothelial cells BBB

Answer 2

• linked together by tight junction- provide physiucal barrier to prevent unwanted moelcules passing between endothelila cells in the brain
• apical membrane- specific transports
  
  • glucose, AA, ions
• basal mebrane
  
  • specif transports
    
    • Glucose AA, ions intot he brain

Question 3

what is the role of astrocytes n the BB

Answer 3

star shaped cells- type of glial cells

provide strucutral support

provide nutrients to neurones

maintain safe neivronemtn for nueornes to survive

has specific transports - glucose potaasium chanels, aqauporins

Question 4

does the BBB allow immune cells to cross

Answer 4

CNS is immune-priilleged- immune cells cannot cross