Blomquist: Highlights

Question 1

Cholesterol side chain cleavage enzyme converts cholesterol to (blank), the precursor to all steroid hormones

Answer 1

pregnenolone

Question 2

What are the C21 steroid hormones?

Answer 2

progesterone, aldosterone, cortisol

Question 3

What are the C19 steroid hormones?

Answer 3

androgens (testosterone)

Question 4

What is a C18 steroid with an aromatic A ring?

Answer 4

estrogen

Question 5

What is a secosteroid with an open B ring and 27 carbons?

Answer 5

vitamin D

Question 6

All steroid hormones go through pregnenolone, a (blank) intermediate, by cleavage of 6 carbons from the side chain of cholesterol.

Answer 6

C21

Question 7

Cytochrome P450 hydroxylations can occur at these positions, among others

Answer 7

11, 17, 21

Question 8

What kind of hormones regulate steroid hormone synthesis?

Answer 8

peptide hormones

Question 9

What do peptide hormones work through?

Answer 9

cAMP and IP3 pathways

Question 10

What are the rate limiting steps of steroid hormone synthesis?

Answer 10

cholesterol esterase
transport into the mito
side chain cleavage

Question 11

Where are steroid hormone receptors located for most steroid hormones?

Answer 11

in the nucleus

Question 12

How are steroid hormones transported in the blood?

Answer 12

Bound to specific proteins

Question 13

The unbound receptor for glucocorticoids and probably aldosterone are in the cytoplasm and undergo (blank) before moving to the nucleus after the steroid hormone binds

Answer 13

dimerization

Question 14

What two binding domains do steroid hormone receptors have?

Answer 14

DNA binding domain and ligand binding domain

Question 15

Steroid hormone receptors function as (blank) and increase or decrease trx of specific genes

Answer 15

dimers

Question 16

These two things have receptors belonging to the same family as steroid receptors

Answer 16

retinoic acid

thyroid hormone