block L1

Question 1

name 5 innate immune cells?

Answer 1

neutrophils, monocytes, NK cells, mast cells, eosinophil, basophil

Question 2

adaptive immune cells?

Answer 2

T lymphocytes, B

lymphoctyes

Question 3

what happens when red blood cells are passed through impedance test?

Answer 3

Haemoglobin contains iron which
changes the flow of current proportional
to iron concentration.

Question 4

formation of blood cells name and where?

Answer 4

haemopoeisis in bone marrow

Question 5

what two types of progenitor cells do haemopoietic cells differentiate into?

Answer 5

common myeloid and common lymphoid

Question 6

what type of cells do common myeloid cells produce?

Answer 6

innate immune cells

Question 7

during foetal development where are the sites of haemopoeisis?

Answer 7

yolk sac, spleen and liver predominantly

Question 8

what is the progenitor cell of platelets?

Answer 8

megakaryocytes

Question 9

what is erythropoeisis regulated by?

Answer 9

erythropoeitin

Question 10

what is platelet formation regulated by?

Answer 10

thrombopoetin

Question 11

what regulates haemopoeisis?

Answer 11

growth factor

Question 12

what is spectrin?

Answer 12

a cytoskeletal protein that forms a scaffold maintaining the integrity and shape of
the RBC membrane.

Question 13

what is ankyrin?

Answer 13

Anchoring of ion channels to spectrin skeleton of RBC

Question 14

what does band 4.1 protein do?

Answer 14

Key role in regulating membrane stability by stabilizing spectin-actin
cytoskeleton interactions, forming the erythrocyte membrane skeleton, mutations in Band 4.1
protein lead to anaemia

Question 15

what does band 3 protein do?

Answer 15

Exchange of chloride and bicarbonate ions across

membrane, it has a key role in CO2 uptake by RBCs.

Question 16

what is the key role of macrophages in the spleen

Answer 16

removal of damaged red blood cells

Question 17

shape of RBCs?

Answer 17

biconcave disc

Question 18

site of thrombopoeitin production?

Answer 18

thrombopoeitin is produced by the liver

and kidney

Question 19

relest of platelets in he blood stream location and how?

Answer 19

Platelet reserves are found in the spleen that

can be released by splenic contraction

Question 20

process of platelet formation?

Answer 20

form from the cytoplasm and bud off from the membrane

Question 21

granules platelets contain and their contents?

Answer 21

Dense Granules: Contain ADP/ATP, calcium and serotonin helps to stimulate aggregation
Lambda Granules: Contain hydrolytic enzymes
Alpha Granules: Platelet factor 4

Question 22

Polycythemia vera?

Answer 22

Polycythemia vera

An excess of red blood cells in the circulation

Question 23

Essential thrombocythemia

Answer 23

Essential thrombocythemia

An excess of platelets

Question 24

Idiopathic myelofibrosis

Answer 24

Too few RBC, too many platelets and WBC

Question 25

Primary polycythemia ?

Answer 25

Genetic problems in RBC

Question 26

Secondary polycythemia

Answer 26

Due to conditions that promote RBC development