Block 4 lecture 8 Flashcards
1
Q
what two signals are needed for T cell activation?
A
- TcR-MHC peptide
2. binding of CD28 to costimulatory molecules CD80/CD86 on APC
2
Q
what happens if only one signal occurs?
A
anergy
3
Q
can dendritic cells stimulate T cells in tissues?
A
no
4
Q
what happens when TcR bind to MHC?
A
structural reorganization and TcR clusters in the center
5
Q
what does azathioprine do?
A
inhibits inflammation
6
Q
what does cyclosporine do?
A
blocks IL2 production and proliferation by T cells
7
Q
negative regulators of T cell production?
A
CTLA4 and PD1
8
Q
how does CTLA4 work?
A
it outcompetes CD28 for binding on CD80/CD86, preventing costimulation
