block 4 leacture 6 Flashcards
where do adaptive responses occur?
secondary lymphoid organs
what do antigen presenting cells do?
process antigen and present as a peptide on an MHC molecule
which part of the T cell receptor interacts with the peptide?
hyper variable loop
What do CD4+ T cells do?
T helper cells respond to external proteins and
help B cells make antigens.
what do CD8 T cells do?
cytotoxic T cells which kill cell with antigen inside
structure of the class 1 MHC molecules?
alpha helicies with a beta plate
where is the peptide help on a class 1 MHC molecule?
peptide sits between the alpha helicies
which type of MHC is expressed on all nucleated cells?
type 1
what holds the peptide in place in MHC type 1?
amino acids with chrges in the alpha beta plate
how many amino acids fit in MHC type 1?
8/9
what is the process of antigen presentation?
proteins are degraded and reformed as peptides by proteosomes, TAP proteins allow 8 amino adcids and provide them to endoplasmic reticulum where they bind to MHC molecules and move to the surface of the cell
which cells notice if a cell is not expressing MHC?
natural killer cells
whats the difference between the MHC molecules in type 1 and type 2?
MHC type two has an open end meaning there is more flexability in the length of peptide and the peptides flop over the end
where do T cells mature?
thymus
what do T cells bind to on APCs?
MHC molecule and peptide
