Bleeding Disorders Flashcards
normal primary haemostatic respons?
platelet plug formation
Von williebrand factor
wall
normal secondary haemostatic response?
fibrin plug formation
what is the most important question to establish bleeding history?
post-surgical bleeding
examples of platelet type bleeding? (6)
mucosal epistaxis purpura menorrhagia GI post-surgical
examples of coagulation factor type bleeding? (3)
articular bleeding
muscle haematoma
CNS
how is haemophilia linked?
X linked
However - every 1 in 3 is new mutation
In haemophilia what does the severity of bleeding depend on?
residual coagulation factor activity
haemophilia clinical features? (5)
hemarthrosis (ankle most common) muscle haematoma CNS bleeding retroperitoneal bleeding post-surgical bleeding
haemophilia complications? (3)
synovitis
chronic haemophilia arthropathy
compartment syndrome
haemophilia diagnosis? (4)
clinical
prolonged APTT
reduced Factor VIII or IX
genetic analysis
treatment of bleeding diathesis? (4)
coagulation factor replacement
desmopressin
tranxamic acid
prophylaxis in severe haemophilia
normal treatment?
splints physiotherapy analgesia synovectomy joint replacement
haemophilia complications?
viruses
inhibitors - anti FVIII ab
how is Von Williebrand disease linked?
autosomal (1 in 200)
what type of bleeding in von williebrand?
platelet type bleeding
