Biological therapeutics

Question 1

Why do we use therapeutic antibodies?

Answer 1

1. They swiftly provide therapeutics to target the disease-related molecules.
2. They have a high level of specificity and a high affinity to the target molecule.
3. They achieve a high level of efficacy and fewer adverse events
4. Can target diverse molecules and they can be applied to a wide range of therapeutic targets.

Question 2

What are the types of therapeutic antibodies.

Answer 2

1. Human
2. Humanised
3. Chimeric
4. Murine antibodies.
   *New nomenclature: –pab for polyclonal antibodies that are pooled monoclonals

Question 3

What are the sources and targets of Infix.

Answer 3

Question 4

What are Fc fusion proteins.

Answer 4

• Alternative to monoclonal antibodies
• Fc domain extends the half-life of therapeutic protein
• Due to interaction with FcRn
• Identified by –cept ending in name