basic science

Question 1

dickkopf

Answer 1

unloaded osteocytes produce dKK1 and sclerostin and both decrease bone mass
work on osteoblasts

Question 2

osteoclast from what stem cell line

Answer 2

hematopoeitic –> monocyte –> osteoclast

Question 3

rank

Answer 3

protein receptor on osteoclast

Question 4

rankL

Answer 4

from osteoblast and osteocyte binds rank, stimulates bone resorption

Question 5

OPG

Answer 5

from osteoblasts, gets between rank and RANKL

Question 6

denosumab

Answer 6

ab to RANKL, inhibits osteoclast formation

Question 7

cathepsin k role

Answer 7

dissolves collagen type one main bone matrix

Question 8

pyknodysostosis

Answer 8

cathepsin k deficiency

Question 9

osteopetrosis

Answer 9

chloride channel AD

no ruffled borer on histology

Question 10

symmetric dwarf

Answer 10

mucopolysaccharidosis

Question 11

short limbed dwarf

Answer 11

achdonroplasia, diastrophic dysplasia

Question 12

short trunk dwarf

Answer 12

SED

Question 13

fingerprint rough ER

Answer 13

comp disorder

Question 14

double patella

Answer 14

MED

Question 15

Jansen type

Answer 15

metaphysical chondrodysplasai
PTHrP receptor AD
severe increase calcium
nephrocalcinosis

Question 16

morquio

Answer 16

defect galactose sulfates
keratan sulfate accumulates
normal IQ
corneal clouding

Question 17

gaucher disease

Answer 17

b glucocerbrosidase
most common lysosomal storage disease
Osteonecrosis
erlenmeyer flaşk femurs

Question 18

ASA mechanism

Answer 18

cox inhibitor, decrase thromboxane A2 and prostaglandins

Question 19

fondaparaninux

Answer 19

binds and inhibits only 10a

Question 20

rivaroxaban

Answer 20

direct xa inhibitor

Question 21

heparin

Answer 21

binds antithrombin 3