Basal Ganglia CC Flashcards
1
Q
signs of parkinsons
A
bradykinesia
rigidity
tremor at rest
need 2/3
onset:
insidious
unilateral to bilateral
2
Q
pathological hallmark of parkinsons
A
loss of DA neurons
3
Q
levodopa
A
drug for parkinsons
L-dopa- precursor for parkinsons
4
Q
amantadine
A
increases DA release and blocks DA uptake
weak, used in conjunction w/ levodopa
5
Q
huntingtons disease
A
hyperdopamine
jerky, random, uncontrolled movements called chorea
psychologic symptoms: apathy, irratiblity, cognitive impairment
atrophy of medium spiny neurons in striatum, specifically in indirect pathway, leaving direct pathway unopposed
6
Q
tourettes syndrome
A
loss of center surround inhibition
