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Anxiolotic drug > Barbiturates > Flashcards

Barbiturates Flashcards

1
Q

What type of group barbiturate?

A

Sedative-hypnotic

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2
Q

What disease that barbiturates treat?

A
  1. Seizure
  2. Insomnia
  3. Preoperative Anxiety
  4. Neonatal withdrawal
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3
Q

What is mechanism of action barbiturate?

A
  1. It activate the GABA-alpha receptor
  2. Open the chloride channel into neuron
  3. It prolong the opening channel
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4
Q

What is classification of barbiturates?

A
  1. Ultra short acting
  2. Short acting
  3. Long acting
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5
Q

What are the name of drugs for ultra short acting barbiturate? (20 minutes)

A
  1. Methohexital
  2. Thiopental
    (MeThio)
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6
Q

What are the name of drugs for short acting barbiturate? (3-8 hours)

A
  1. Secobarbital
  2. Pentobarbital
    “Barbital”
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7
Q

What are the name of drugs for long acting barbiturate?(1-2 days)

A
  1. Phenobarbital
  2. Primidone
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8
Q

Can barbiturate reduce awakening during sleep?

A

Yes

BUT, tolerance can develop in 2 weeks, if discontinue can cause rebound which in worse insomnia

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9
Q

Can barbiturate treat status epilepticus?

A

Yes

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10
Q

Can Barbiturate treat tonic-clonic and partial seizure?

A

Yes

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11
Q

What drug that use for ECT?

A

Methohexital(short acting)

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12
Q

What is contraindication for barbiturate?

A
  1. Acute intermittent porphyria
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13
Q

Adverse effect
-Can barbiturate cause confusion?

A

Yes

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14
Q

Adverse effect
-Can barbiturate cause nausea?

A

Yes

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15
Q

Adverse effect
-Can barbiturate cause nystagmus?

A

Yes

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16
Q

Barbiturate has withdrawal and overdose symptoms?

A

Yes

17
Q

The most widely used anxiolytic drug?

A

Benzodiazepine

18
Q

Reason?

A

It is safer and more effective

19
Q

Can barbiturate do anterograde amnesia?

A

Yes

20
Q

Can barbiturate do retrograde amnesia?

A

No

21
Q

Higher dose of benzo can cause what?

A

Muscle relaxant

22
Q

Low dose of benzo can cause what?

A

Reduce anxiety

23
Q

What type of anxiety that can benzodiazepine can be used?

A
  1. Generalized anxiety disorder
  2. Social anxiety
  3. Performance anxiety
24
Q

Can benzodiazepine decrease latency(delay) of sleep and increase non- REM sleep?

A

Yes

25
Q

What name of benzodiazepine can treat status epilepticus?

A

Lorazepam & Diazepam

26
Q

Short acting benzodiazepine? (3-8 hours)

A

Oxazepam & Triazolam

27
Q

Intermediate acting benzodiazepine? (10-20 hours)

A

Lorazepam & Alprazolam

28
Q

Long acting benzodiazepine? (1-3 days)

A

Diazepam & Flurazepam?

29
Q

Two adverse effect benzo?

A
  1. Drowsiness
  2. Confusion
30
Q
A

Anxiolotic drug (1 decks)

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