Autoimmunity Flashcards
1
Q
Who is typically affected by myasthenia gravis?
A
Females more than males
Age 30-40 in females
Age 60+ in males
2
Q
What type of cancer is myasthenia gravis associated with?
A
Thymomas
3
Q
What are the clinical features of myasthenia gravis?
A
Easy fatigability
- Gets worse throughout the day
- Worse with activity/exercise/use
May be localised or generalised
Typically affects eyes first
- Bilateral ptosis or diplopia
Limb weakness or general weakness
May develop ‘myasthenic snarl’ on smiling
4
Q
What are the investigations for myasthenia gravis?
A
Auto-antibody testing
Pulmonary function tests
CT scan of thorax
5
Q
What is the management of myasthenia gravis?
A
Anticholinesterase inhibitors
Immunosuppression
Consider thymectomy
