Autoimmune and HIV Flashcards
Autoimmune diseases Circulating antibodies ANA Abnormal Titer - 1/40 or 1/80
Connective Tissue Disease
1/160 Titer
NOT diagnostic.
Acute QT Subacute QT Chronic QT
Lupus Erythematous Variants Anti-histone antibodies
Butterfly rash Anti-DsDNA
Acute cutaneous lupus
V of neck rash Extensors Annular/polycyclic plaques Anti-Ro
Subacute cutaneous lupus
Early lesions are well demarcated and scale/scar Late lesions occur with atrophic plaques, central scarring and telangiectasia
Chronic cutaneous lupus
15x more common in women, endothelial damage is suspected pathology
Scleroderma
Sclerodactylyl, Raynaud’s with hyperpigmentation Anti-Scl-70
Systemic Scleroderma
Plaque - sclerotic and scar-like Deep - deep tissue necrosis En coupe de saber - linear on forhead/scalp Anti-fibrillin-1
Morphea
What is CREST?
Calcinosis cutis Raynaud’s Esophageal dysfunction Sclerodactyly Telangiectasia
Anti-centrome
CREST Syndrome
Proximal extensor inflammatory myopathy.
Dermatomyositis/Polymyositis
Gottron’s papules/Gottron’s sign
Cutaneous DM/PM
Proximal muscle weakness and pulmonary fibrosis Anti-Jo1
Systemic DM/PM
Females in their 30/40s, sausage fingers, synovitis, myositis, Raynaud’s, and acrosclerosis Anti-RNP
MCTD
Inflammation of cartilaginous tissue, ears Recurrent articular chondritis, cochlear and vestibular damage Increased ESR and antibodies to type II collagen
Relapsing polychondritis
MOST common infection in the early stage of HIV Malassezia furfur Erythema with greasy scaling
Seborrheic dermatitis
Often caused by immune dysregulation
Psoriasis
Mononucleosis-like illness with fever. Maculopapular rash with oral and genital ulcers
Xanthem
Group A strep MOST commonly staph aureus
Type I HIV
Extensive infections such as CMV and HPV
Type II HIV
Opportunistic infections such as fungal, mycobacteria, and Pneumocystis jiroveci
Type III HIV
Metastatic infections from systemic diseases
Type IV HIV
Infections specific to AIDS such as oral hairy leukoplakia and Kaposi’s
Type V HIV
