Asthma In Children

Question 1

What is theMost common chronic respiratory disorder in childhood?

Answer 1

Asthma

Question 2

TH1-type cytokines in asthma include

Answer 2

IL-2, IL-12, IL-18, and tumour

necrosis factor beta

Question 3

TH2-type cytokines In asthma include..

Answer 3

(interleukins IL-4, IL-5, IL-9, IL-13) regulate

eosinophilia, mast cell growth, IgE and mucus production

Question 4

What are the inhaler devices that you know?

Answer 4

Metered dose inhaler(MDI) +/- spacer
Dry powder inhaler (DPI)
Nebulizer

Question 5

Treatment of acute asthma

Answer 5

• Oxygen
• Beta 2 agonist nebulised/bolus
• Steroids- oral/iv
• IV infusion of:
magnesium/aminophylline/salbutamol
• ITU
• Assisted Ventilation
• Frequent REVIEW

Question 6

Criteria for admission to hospital in asthma patient.

Answer 6

• Poor response to bronchodilator therapy
• Exhaustion
• Marked reduction in predicted (or usual best) PEFR or FEV 1 (<50%)
• Reduced oxygen saturation (<92% in air)

Question 7

Management of Acute Asthma

Answer 7

High dose bronchodilator (salbutamol)
• MDI + spacer
• Nebulizer + Oxygen
• Ipratropium bromide : nebulizer
• Corticosteroids: oral e.g. prednisolone 3-7 days, parenteral or nebulized
• IV treatment for severe / Life threatening asthma
• IV Magnesium sulphate, aminophylline, or intravenous salbutamol
• Oxygen
• ICU Mechanical Ventilation
• Antibiotics only if infection