Approach to Gluten Sensitivity Disorders

Question 1

what part of the GI tract does celiac disease most commonly affect?

Answer 1

distal duodenum and proximal jejunum

Question 2

common non-GI presentations of celiac disease (3)

Answer 2

osteopenia/osteoporosis (reduced bone density), iron deficiency anemia, dermatitis herpetiformis

Question 3

histology of small bowel in celiac disease

Answer 3

villous atrophy, lymphocytes in lamina propria

Question 4

genetic testing pitfalls in celiac disease

Answer 4

40% of persons of European ancestry are DQ2 or DQ8 positive so positive result is of little value

Question 5

malignant complication of celiac disease

Answer 5

T-cell lymphoma