Appetite Modifying

Question 1

What and where is the centre in which these drugs target?

Answer 1

satiety centre in the hypothalamus

Question 2

what hormones and NTs are involved?

Answer 2

cholecystokinin, glucagon like petide 1 (GLP-1)
nefstatin/ghreline
NTs: serotonin, peptide YY and NE

Question 3

What are 4 common appetite stimulants used in vet med?

Answer 3

Diazapam (valium)
cyptoheptadine (periactin)
mirtazapine (remeron)
glucocorticoid

Question 4

What is the MOA and use of diazapam?

Answer 4

appetite stimulant in cats

GABA induced effects and central inhibition of the satiety centre

Question 5

What is the MOA and use of cyptoheptadine?

Answer 5

antihistamine and serotonin receptor (5HT2) blocker
inhibits serotonergic receptors which control satiety
used in cats
hit or miss
also antipruretic effects

Question 6

what is the MOA use and SE of Mirtazapine?

Answer 6

NaSSA (noradrenergic slective serotonin antagonist) - human antidepressant

MOA:
stimulates NE release
increases specific serotonergic (5HT1)
potent antagonist of 5HT2 (likely cause of increase appetite)
potent antagonist of 5HT3 (antinausea/emetic)
potent antagonist of H1 (histamine) sedation

SE: vocalization

Question 7

how is Mirtazapine excreted?

Answer 7

hepatic and renal

careful with disease

Question 8

What is the use and MOA of Glucocorticoids?

Answer 8

polyphagia is common side effect
- often used in palliative cases
MOA: more perking up and wanting to eat