APEA Urology Prescribing

Question 1

Mirabegron (Myrbetriq) should be used with caution in combination with:

Answer 1

Metoprolol

mirabegron is a moderate CYPD6 inhibitor, Metoprolol is a substrate of this and the combination may increase exposure causing increased risk of hypotension, bradycardia, AV Block etc…

Question 2

Qxybutynin (Ditropan), used in the treatment of dysuria, is classified as an:

Answer 2

Anti-spasmotic agent

Question 3

Thiazide diuretics are contraindicated in patients who have:

Answer 3

A hypersensitivity to sulfonamides

Question 3

ARBs act by

Answer 3

inhibit the binding of angiotension II to angiotension i receptor sites on vascular smooth muscle

Question 4

desmopression acetate (DDAVP)

Answer 4

for enuresis
- should be held in the presence of fever or diarrhea

Question 5

A few first gen cephalosporins, such as cephalexin (Keflex), have some gram-negative coverage against:

Answer 5

E coli