Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Clinical Prep > Anxiety and Depression > Flashcards

Anxiety and Depression Flashcards

1
Q

TCAs

A

Considered 2nd line for Anxiety, but not used often d/t SE and Overdose potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Overdose of TCA

A

TORSADES de POINTE
Coma
Acidosis
Respiratory depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

TCA risk

A

Seretonin synd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TCAs act on what receptors

A

NE and Seretonin

also: histamine, a1, cholinergic (which causes the SE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

TCAs

A

2: Notriptyline, Desipramine
3: Amitriptyline, Imipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Indications for TCAs

A

Anxiety (2nd line)
Chronic pain
Fibro
Enuresis (bedwetting)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When using TCAs, since they act on Serotonin receptors, caution of

A

Seretonin syndrome

do NOT combine with MAOIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drugs that act on 5HT (Serotonin) receptors therefore we need to be cautious of Serotonin syndrome

A

TCA, SNRI, SSRI, MAOIs

Nortriptyline, Amitriptyline, Prozac, Zoloft, Paxil, Effexor, Cymbalta, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Generic name: Fluoxetine

SSRI

A

Brand name: Prozac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Generic name: Sertraline

SSRI

A

Brand name: Zoloft

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Generic name: Paroxetine

SSRI

A

Brand name: Paxil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Generic name: Citalopram

SSRI

A

Brand name: Celexa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Generic name: Escitalopram

SSRI

A

Brand name: Lexapro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Generic names:

Fluoxetine
Sertraline
Paroxetine
Citalopram
Escitalopram

are all

A

SSRIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Brand names:

Prozac
Zoloft
Paxil
Celexa
Lexapro

are all

A

SSRIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Fluoxetine, aka

A

Prozac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Sertraline, aka

A

Zoloft

“the S and Z at beg look the same”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Citalopram, aka

A

Celexa

“both have C at the beg”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Escitalopram, aka

A

Lexapro

“both have E towards the beg”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Unique uses of Paroxetine (Paxil)

A

Social anxiety

OCD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Disadv of Fluoxetine (Prozac)

A

More drug intxns than other SSRIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Good thing about Sertraline (Zoloft)

A

Least likely for drug intxns

Preferred for Elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

OLD PPL with depression

A

Zoloft/ Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

DOC for Depression

A

Citalopram (Celexa)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Anxiety and Insomnia can occur as SE of
Fluoxetine (Prozac) | Sertraline (Zoloft)
26
Fluoxetine (Prozac)
more drug intxns | Can cause insomnia
27
Two meds to keep in mind, avoid using together
B- blockers "lol" and SSRIs (antidepressants) Can cause Hypotension and Heart block
28
A ton of meds to be cautious of using with SSRI Antidepressants d/t caution of: SEROTONIN SYNDROME
``` MAOIs St Johns Wort Amphetamines Meperidine (opioid) TCAs SNRIs ``` Nortriptyline, Amitriptyline, Prozac, Zoloft, Paxil, Effexor, Cymbalta, etc.
29
If you are using SSRI: prozac, zoloft, paxil, celexa, etc.... keep in mind that _____ will not work as effectively
Codeine- its conversion to active compound is blocked
30
SNRIs
inhibit NE and Serotonin
31
The two SNRIs | NE and Seretonin
Effexor | Cymbalta
32
Venlaxafine, aka SNRI
Effexor
33
Duloxetine, aka SNRI
Cymbalta
34
Venlaxafine | Duloxetine
SNRIs
35
SE of Venlaxafine (Effexor)
Increase BP
36
SE of Duloxetine (Cymbalta)
Hepatotoxic (liver!) | Glaucoma (acute angle closure)
37
When can you NOT use Bupropion (Wellbutrin)?
hx of Seizures
38
What neurotransmitters are a/w Bupropion (Wellbutrin)
Mainly Dopamine (DA) but minimally NE and 5HT (seretonin)
39
When to use Wellbutrin (Bupropion)?
When others havent worked | When pt doesn't want the loss of Libido SE
40
St John Wort
for Mild depression Mechanism unsure- may block reuptake or inhibit MAO Photosensitivity do NOT combine w other SSRI- risk of Serotonin synd
41
SSRIs that are ok while breastfeeding
Sertraline (Zoloft) | Paroxetine (Paxil)
42
Which of the two ok for breastfeeding is the DOC while breastfeeding? SSRIs
Zoloft aka Sertraline
43
DOC for Acute Anxiety short term, self limiting
Benzos
44
DOC for GAD
1st line: SSRI, SNRI 2nd line: TCA Abuse concern: Buspirone, Hydroxyzine
45
Most useful for short term insomnia
Benzos
46
GABA CNS depresant
Major inhibitory neurotransmitter Relives anxiety and promotes sedation
47
Activation of GABA receptors
allows Cl- to enter cell, hyperpolarizing causing depression of electrical activity
48
Drugs that work independently of GABA
Buspirone | Ramelteon
49
What is Hydroxyzine's business in Anxiety?
It's an Antihistamine used as anti-anxiety med No abuse potential, good for recovering addicts
50
DOC for Recovering Addicts suffering from Anxiety
Hydroxyzine Buspirone low abuse potential
51
Hydrozyzine (Vistaril) is also used in _____ in addition to Anxiety
Parkinson
52
Barbs independent of GABA
Marked CNS depression, causes Euphoria Drug of ABUSE!!
53
CONTRA of Barb
Porphyria (abnormal heme synthesis) Pulmonary insuff Supra-additive effects when combined w other depressants (i.e. Alcohol)
54
When to use Barbs?
Short acting: Induction of anesthesia Long acting: Anticonvulsants for SEIZURES
55
Barbs
Thipental- induce anesthesia Phenobarbitol- tx Seizure, it's an Anti convulsant
56
Why are Barbs so dangerous?
NO ceiling effect Coma, resp depression, dec BP DO NOT GIVE STIMULANT to combat these effects
57
How to treat Barb OD?
Supportive | Diuretics, Alkalization of urine
58
Benzos indication
Anxiety Insomnia but dec in Anxiety often accompanied by drowsiness
59
Short acting Benzo
Midazolam
60
Intmdt acting Benzo
Alprazolam Oxazepam Lorazepam
61
Long acting Benzo
Diazepam | Flurazepam
62
Do NOT use Benzos to treat Anxiety if any of these other things are present
OCD Panic disorder PTSD Anxiety in child/teen instead, use SSRI
63
Benzo that's used in prep for Anesthesia for Short surgical procedures
Midazolam
64
Benzos DOC for Status Epilepticus
Diazepam | Lorazepam
65
The Z drugs used just for Insomnia
Zolpidem (Ambien) Zaleplon (Sonata) Eszopiclone (Lunesta) strong and rapid sedative effects
66
Which of the Z drugs have short duration of action, therefore NO DROWSY MORNING
Zolpidem (Ambien) | Zaleplon (Sonata)
67
Which Z drug stands out for having drowsy morning effect bc it has a longer duration of action
Eszopiclone (lunesta)
68
Overall, the safety of the Z drugs is
GOOD | high margin of safety
69
Ramelteon (Rozerem)
Melatonin analogue, resets sleep wake cycle Promotes sleepy w/ no GABA effect
70
Buspirone
agonist for Seretonin Indications: GAD or Anxiety w Depression ADHD PMS Low addiction potential
71
Buspirone and Breastfeeding
"Caution" not enough data
72
SSRI to reach for if you are breastfeeding
Zoloft (sertraline)
73
SE of Effexor aka Venlaxafine
Increase BP --> HTN
74
SE of Cymbalta, aka Duloxetine
Hepatotoxic | Glaucoma

Clinical Prep (41 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions