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Farmacologie > Antispastice intestinale > Flashcards

Antispastice intestinale Flashcards

1
Q

Tipuri de antispastice

A

Anticolinergice

Musculotrope (papaverinice)

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2
Q

Antispastice anticolinergice - mecanism de actiune

A

Blocarea RM3 de pe musc neteda

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3
Q

Indicatii antispastice anticolinergice

A

SII
Diskinezii/ stari spastice gastrice, duodenale, intestinale
Enurezis nocturn, hipertonie vezicala
Colici reno-ureterale

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4
Q

Anticolinergice - RA

A

xerostomie, disfagie, dificultati in vorbire
constipatie
tulburari de vedere
agravare glaucom
mictiuni dificile, retentie acuta de urina
tk, aritmii
sedare

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5
Q

Anticolinergice - CI

A

Glaucom
Adenom de prostata
FiA, IC
Constipatie

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6
Q

Anticolinergice - reprezentanti

A 
Atropina si scopolamina
Dyciclomina si hyosciamina
Bromura de butilscopolamina
Propantelina
Oxifenoniu
Bromura de clidiniu si de otiloniu
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7
Q

Antispastice musculotrope

A 
Papaverina
Mebeverina
Drotaverina
Alverina
Pitofenona
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8
Q

Papaverina - mecanism de actiune

A

Inhibitia neselectiva a fosfodiesterazelor si cresterea cAMP, blocarea neselectiva a canalelor de Ca -> relaxarea musculaturi netede + VD

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9
Q

Papaverina - indicatii

A

Colici biliare, intestinale, reno-ureterale

Dismenoree

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10
Q

Papaverina - RA

A

Congestia fetei
Somnolenta
Cresterea transaminazelor
La injectare rapida iv - aritmii, BAV

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11
Q

Papaverina - CI

A

HTIC

BAV

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12
Q

Mebeverina - mecanism de actiune

A

blocarea canalelor de Na, K, Ca mb la niv fb musc netede

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13
Q

Mebeverina - indicatii

A

colopatii functionale
SII
stari de hipermotilitate

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14
Q

Drotaverina - mecanism de actiune

A

Antispastic
Vasodilatator
Slab blocant al Rbeta1

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15
Q

Drotaverina - indicatii

A

Colici intestinale si biliare

Afectiuni vasculo-spastice

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16
Q

Alverina - indicatii

A

SII + simeticona

Dismenoree

17
Q

Piafen

A

Pitafenona + fenpiramida (antispastic anticolinergic) + metamizol (analgezic)

18
Q

Trimebutina - mecanism de actiune

A

Reglator al motilitatii digestive (actiune duala) prin + R opioizi miu, kappa, delta
Analgezic local (blocarea canalelor de Na) - amelioreaza durerea din SII
X canalelor de Ca de tip L
X canalelor de K

19
Q

Trimebutina - indicatii

A

Dispepsii functionale
SII
Constipatia idiopatica
Patologie mixta (SII + BRGE sau dispepsie functionala)
Diskinezii biliare hipotone
Afectiuni organice ale TGI
Copii: colici, abdomen dureros, tulb de tranzit

20
Q

Trimebutina - CI

A

Legate de excipienti (lactoza) - sdr de malabsorbtie (galactozemie congenitala, malabsorbtia glu, deficit de lactaza)

Farmacologie (8 decks)

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