Antipsychotics Flashcards
What are some examples of typical antipsychotics?
haloperidol
chlorpromazine
thioridazine
fluphenazine
Are extrapyramidal side effects worse in typical or atypical antipsychotics?
typical
What are some side effects of antipsychotics?
sedation weight gain extrapyramidal symptoms and parkinsonism prolonged QTc interval increased prolactin
What are extrapyramidal symptoms?
parkinsonism
tardive dyskinesia
akathisia
acute dystonia
What is the mechanism of action of typical antipsychotics?
block dopamine 2 receptors
What are some examples of atypical antipsychotics?
rispiridone olanzapine quetiapine clozapine - for resistant illness due to side effects aripiprazole
What is the mechanism of action of atypical antipsychotics?
dopamine and 5HT antagonism
Which are worse for metabolic syndrome - typical or atypical?
atypical
Why do you monitor FBC with clozapine use?
risk of agranulocytosis
Why can’t you use clozapine or olanzapine in pregnancy?
increased risk of gestational diabetes
What happens if someone misses their dose of clozapine for over 48 hours?
needs to be started again and titrated up slowly (start from the beginning)
What do antipsychotics increase the risk of in elderly patients?
stroke and VTE
