Antibiotic Drugs

Question 1

What antibiotics are BACTERICIDAL?

Answer 1

Very Finely Proficent At Murder

(Vancomycin, Fluoroquinolones, Penicillin, Aminoglycosides, Metronidazole)

Question 2

What antibiotics are BACTERIOSTATIC?

Answer 2

We’re ECSTaTiC about bacteriostatics

(Erythromycin, Clindamycin, Sulfamethoxazole, Trimethoprim, Tetracycline, Chloramphenicol)

Question 3

Ampicillin/Amoxicillin

Answer 3

AMPicillin = AMPed up penicillin

amOxicillin = greater Oral bioavailability

Question 4

Describe the antimicrobial coverage of extended spectrum penicillins

Answer 4

amoxicillin HELPS kill Enterococci

(Haemophilus influenza, Eschericia coli, Listeria monocytogenes, Proteus mirabilis, Salmonella sp., Enterococci)

Question 5

Antipseudomonal Penicillins

Answer 5

TCP: Takes Care of Pseudomonas

(Ticarcillin, Carbenicillin, Piperacillin)

Question 6

Which microbes are covered by the spectrum activity of first generation cephalosporins?

Answer 6

PEcKs FIRST

(Proteus mirabilis, Eschericia coli, Klebsiella pneumoniae)

Question 7

How do you remember the first generation cephalosporins?

Answer 7

FADer, help me FAZ my PHarmacology boards! (ceFADroxil, ceFAZolin, cePHalothin, cePHapirin, cePHradine, cePHalexin)

Question 8

Which microbes are covered by the spectrum activity of second generation cephalosporins?

Answer 8

HEN PEcKS

(Haemophilus influenzae, Enterobacter aerogenes, Neisseria spp., Proteus mirabilis, Eschirichia coli, Klebsiella pneumoniae, Serratia marcescens)

Question 9

Second Generation Cephalosporins

Answer 9

In a FAMily gathering, you see your FOXy cousin wearing a FURcoat and drinking TEa

(CeFAMandole, CeFOXitin, CeFURoxime, CefoTEtan)

Question 10

Third Generation Cephalosporins

Answer 10

FEnge PO ng PERA to FIX my TTTTV!

(CeFEtamet, CefPOdoxime, CefoPERAzone, CeFIXime, CefTriaxone, CefTazidime, CefoTaxie, CedTzoxime, CefTibuten)

Question 11

Antipseudomonal Cephalosporins

Answer 11

Ceftazidimie, Cefepime, Cefoperazone

Question 12

Which antibiotics are considered drugs of last resort?

Answer 12

I AM your Last Shot at Victory

(Imipenem, Amikacin, Meropenem, Linezolid, Streptogramins, Vancomycin)

Question 13

Protein Synthesis Inhibitors

Answer 13

ATCELLS

(Aminoglycosides, Tetracyclines, Chloramphenicol, Erythromycin (Marolides), Lincosamides, Linezolid, Streptogramins)

Question 14

Tetracyclines

Answer 14

T = TeTracyclines = Block aTTachment of T-RNA to acceptor site

Question 15

Clindamycin vs Metronidazole

Answer 15

CLINDAMYCIN for anaerobic infections ABOVE the diaphragm

METRONIDAZOLE for anaerobic infections BELOW the diaphragm

Question 16

Aminoglycosides

Answer 16

AminOglycosides require O2 for transport

They won’t work under anaerobic conditions

Question 17

Aminoglycosides

Answer 17

Mean GNATS can NOT kill anaerobes

(Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotoxicity, Ototoxicity, Teratogen)

Question 18

Isoniazid

Answer 18

INH

(Injures Neurons and Hepatocytes)

Question 19

Rifampicin

Answer 19

R = Rifampicin

(RNA polymerase inhibitor, Red-orange body fluids, Rapid development, Revs up cytochrom P450 inducer)

Question 20

Which anti-TB drugs are hepatotoxic?

Answer 20

ISO a Red PYRe (I saw a red fire!)

ISOniazid < Rifampin < PYRazinamide

Question 21

NNRTIs (Non-Nucleoside RT inhibitors)

Answer 21

Never Ever Deliver nucleosides OR DENR

(Nevirapin, Efavirenz, Delavirdine)

Question 22

Protease inhibitors

Answer 22

NAVIR (never) TEASE a proTEASE

(All protease inhibitors end with -navir)

Question 23

Amantadine

Answer 23

A man to dine takes off his coat

(Amantadine prevents uncoating)

Amantadine: for influenza A and rubellA, causes problems with the cerebellA